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Repurposing Fenofibrate in Modulating AMPK/NLRP3 Inflammasome in Patients With Ulcerative Colitis
Sponsor: Tanta University
Summary
Fibrates, specific pharmacological agonists of PPARα, have been widely used to treat hypercholesterolemia and hypertriglyceridemia. Apart from their metabolic action, anti-inflammatory properties of fibrates have been described, including inhibition of NF-kappa B signaling and pro-inflammatory cytokine production. 4 Fenofibrate, an important peroxisome proliferator-activated receptor-a (PPAR- α) agonist, is widely used in clinical as a triglyceride (TG)-lowering agent
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2023-03-20
Completion Date
2024-04-20
Last Updated
2026-10-13
Healthy Volunteers
No
Conditions
Interventions
Mesalamine
mesalamine is the cornerstone used for the treatment of mild to moderate ulcerative colitis
Fenofibrate
Fibrates, which are specific pharmacological agonists of PPARα, have been widely used in the treatment for hypercholesterolemia and hypertriglyceridemia
Locations (1)
Faculty of Medicine, Menoufia University
Tanta, Shebeen El-Kom, Egypt