Clinical Research Directory

Inclusion Criteria: 1. Age between 18-40 years old; 2. Meeting the diagnostic criteria for schizophrenia in DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition); 3. BMI ≥ 25kg/m 2 or over 10% weight gain after taking antipsychotics in the last year; 4. Not receiving TMS therapy in the past month; 5. Using no more than two antipsychotic medications (including olanzapine, haloperidol, amisulpride, asenapine, risperidone, paliperidone, clozapine, quetiapine, iloperidone, chlorpromazine, sertindole, zotepine), not using antidepressants, mood stabilizers and other drugs, but allowing short-term use of benzodiazepines, benzhexol and propranolol; 6. Signing written informed consents voluntarily. Exclusion Criteria: 1. Other severe mental illnesses, mental retardation, dementia and severe cognitive impairment according to diagnostic criteria of ICD-10 or DSM-5; 2. Abnormal brain structure or function owing to any major physical disease, neurological disease, traumatic brain injury, etc.; 3. Metallic implants, pacemakers, epilepsy history or other contraindications of TMS; 4. Suicidal thoughts or behaviors; 5. Alcohol or substance abuse; 6. Pregnant or lactating women; 7. Other contraindications of MRI; 8. Receiving regular MECT, or weight-loss therapy in the latest month; 9. Other abnormal examination results considered to be inappropriate for inclusion by researchers.