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Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia
Sponsor: Mansoura University
Summary
Cesarean birth is a common surgical procedure. After cesarean birth, postsurgical pain may delay recovery, interfere with maternal-newborn bonding, and reduce the breastfeeding if not adequately controlled. Postpartum analgesia has become a common concern. Many adjuvant drugs used for peripheral nerve blocks as( N-methyl-d-aspartate (NMDA) receptor antagonists , Magnesium , Ephedrine , Dexamesathone , Fentanyl , Midazolam and Neostigmine) The potential of neostigmine as an adjuvant in peripheral nerve block is through its action to increase acetylcholine at muscarinic junctions of peripheral nerves. 500 mcg neostigmine was used as adjuvant to local anesthetic in an axillary brachial plexus block leads to decreased pain and less use of analgesics in the first 24 hours postoperatively with no incidence of adverse effects.
Official title: Efficacy of Neostigmine as an Adjuvant to Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block as a Postoperative Analgesia After Caesarean Delivery.
Key Details
Gender
FEMALE
Age Range
19 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
58
Start Date
2027-12-01
Completion Date
2029-12-01
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Bupivacaine-Neostigmine
20 mL bupivacaine 0.25% plus 1 mL Neostigmine (500 mcg)
Bupivacaine
20 mL bupivacaine 0.25% plus 1 mL normal saline 0.9%
Locations (1)
Mansoura University-Emergency hospital-ICU
El Mansoura, Mansoura, Egypt