Clinical Research Directory

Inclusion Criteria: OLDER ADULTS WITH SIHD AND MCC * Age ≥65 years * ≥ 2 Multiple Chronic Conditions as defined by Centers for Medicare and Medicaid Services (CMS) * Diagnosis of Symptomatic Stable Ischemic Heart Disease with plans to initiate medical therapy identified by at least one of the following: 1. positive non-invasive functional or anatomic testing suggestive of obstructive coronary artery disease 2. coronary angiography with stenosis ≥70% in a coronary artery ≥2 mm in diameter or ≥50% stenosis of left main 3. Invasive coronary angiography with positive physiologic testing in at least one vessel (FFR ≤ 0.80 or iFR ≤0.89) CAREGIVERS * Age ≥ 18 years * Identified as caregiver of LIVEBETTER participant Exclusion Criteria: OLDER ADULTS WITH SIHD AND MCC * Current taking (both) a beta-blocker AND a calcium channel blocker\* * Contraindication to beta-blockers or calcium channel blockers including: 1. significant hypotension 2. high grade AV block 3. severe symptomatic bradycardia 4. severe obstructive lung disease * Documented intolerance to beta-blockers or calcium channel blockers * Probable or definite high-risk coronary artery disease including unrevascularized left main disease and/or unrevascularized multi-vessel disease including the proximal left anterior descending (LAD) artery with plans for immediate complete revascularization * Plans for complete revascularization within 2 weeks * Clear clinical indication for beta-blockers or calcium channel blockers that precludes dose adjustment or crossover: 1. Diagnosis of acute coronary syndrome (ACS) with reduced ejection fraction within past year 2. Heart failure with reduced ejection fraction (HFrEF) within past year * Actively participating in another clinical trial involving an investigational medication or device * Primary language other than English or Spanish * Inability to complete follow-up (e.g. life expectancy \<12 months, impaired decision-making determined by validated instrument) * Previously enrolled in LIVEBETTER * Refused informed consent CAREGIVERS * Professional caregiver (i.e. not a relative or close friend of the participant) * Primary language other than English or Spanish * Inability to complete follow-up * Previously enrolled in LIVEBETTER * Refused informed consent