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Treatment Strategies for IgG4-RD Patients With Internal Organ Involvement
Sponsor: Peking Union Medical College Hospital
Summary
This study has been designed as a 18-month, open-label randomized controlled clinical trial. The study aims to compare the efficacy and safety of two treatment strategies in active IgG4-RD patients with internal organ involvement during maintenance remission period: low dose mycophenolate mofetil group and leflunomide group.
Official title: Efficacy of Mycophenolate Mofetil Versus Leflunomide as Maintenance Treatment for IgG4-RD Patients With Internal Organ Involvement
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2022-07-01
Completion Date
2024-12-31
Last Updated
2024-05-28
Healthy Volunteers
No
Conditions
Interventions
Prednisone and Mycophenolate Mofetil
Patients are treated with glucocorticoids and mycophenolate mofetil in remission induction period (6 months), during which glucocorticoids are tapered regularly and discontinued in 6 months.
Mycophenolate Mofetil
Patients are treated with low dose mycophenolate (1-1.5g/day) during remission maintenance period for 12 months.
Leflunomide
Patients are treated with leflunomide (20 mg/day) during remission maintenance period for 12 months.
Locations (1)
Peking Union Medical College Hospital
Beijing, China