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Non-Inferiority Trial of TrIGR for PTSD
Sponsor: VA Office of Research and Development
Summary
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like cognitive processing therapy (CPT), is the next critical question that this study will seek to answer. 158 Veterans across two VA sites will be randomized to TrIGR or CPT to evaluate changes in PTSD, depression, guilt and shame symptoms across the two treatments.
Official title: Non-Inferiority Trial of Trauma Informed Guilt Reduction Therapy (TrIGR) for PTSD
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
158
Start Date
2023-06-01
Completion Date
2027-09-30
Last Updated
2025-06-26
Healthy Volunteers
No
Conditions
Interventions
Trauma Informed Guilt Reduction Therapy
behavioral intervention aimed to reduce trauma-related guilt and shame
Cognitive Processing Therapy
behavioral intervention aimed at reducing PTSD symptoms
Locations (2)
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States
James A. Haley Veterans' Hospital, Tampa, FL
Tampa, Florida, United States