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Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)
Sponsor: Capital Medical University
Summary
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of ischemic post-conditioning incrementally for a longer duration of up to 5 min × 4 cycles in stroke patients undergoing mechanical thrombectomy. The purpose of this study is to further determine the efficacy and safety of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.
Official title: Efficacy and Safety of Ischemic Post-conditioning in Patients with Acute Ischemic Stroke After Mechanical Thrombectomy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2023-11-01
Completion Date
2026-02-01
Last Updated
2025-03-26
Healthy Volunteers
No
Conditions
Interventions
Mechanical thrombectomy combined with ischemic post-conditioning
Ischemic post-conditioning will be applied after successful recanalization of the culprit artery achieve by thrombectomy. Ischemic post-conditioning consists of briefly repeated 4 cycles × 2 minutes of occlusion and reperfusion (equal duration) of the initially occluded artery using a balloon.
Mechanical thrombectomy alone
Successful recanalization was achieved by mechanical thrombectomy without subsequent ischemic post-conditioning.
Locations (1)
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China