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Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound
Sponsor: Medical University of South Carolina
Summary
Through the BrainBox Initiative, investigators propose to study the effects of motor tFUS on Motor Evoked Potentials (MEPs) and GABA and Glutamate Concentrations in the Brain.
Official title: Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound (fUS) Over the Motor Cortex
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2026-05
Completion Date
2027-12-30
Last Updated
2026-02-27
Healthy Volunteers
Yes
Conditions
Interventions
Focused Ultrasound Stimulation
This aim will test whether motor tFUS parameters thought to be excitatory (50% duty cycle) vs. inhibitory (5% duty cycle) elicit their predicted effects on MEPs before and after each of three stimulation blocks, using 50 MEPs at each time point.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States