Clinical Research Directory

Myofascial Pain Syndrome with active and/or latent TrPs Inclusion Criteria: 1. Ages: 18-80 2. Myofascial Pain Syndrome with active and/or latent TrPs, as diagnosed by a pain specialist, with involvement of the trapezius meeting criteria (detailed in "Methods")) 3. Capacity to manage breakthrough pain medications during the study with only acetaminophen Exclusion Criteria: 1. Presence of radicular pain, superimposed neuromuscular disease, or condition 2. Fibromyalgia or other generalized pain condition 3. Opioid use 4. Active mood or substance use disorder 5. Taking or unable to wean off pain medications that directly affect neuronal or muscle excitability at least 2 weeks prior to study enrollment and remain off for the duration of the study: gabapentin, pregabalin, topiramate, carbamazepine, oxcarbazepine, valproic acid, tricyclic antidepressants (such as nortriptyline and amitriptyline), tizanidine, cyclobenzaprine, carisoprodol, methocarbamol, benzodiazepines 6. Skin allergy or sensitivity that would preclude the use of adhesive electrodes 7. Systemic or psychiatric illness that in the opinion of the Site Investigator would interfere with the individual's ability to participate in the trial. 8. Anticoagulation (with coumadin, clopidogrel, or direct oral anticoagulants; aspirin acceptable). Healthy volunteers Inclusion Criteria: 1\. Ages: 18-80 Exclusion Criteria: 1. Presence of radicular, myofascial, or generalized pain, superimposed neuromuscular disease or condition 2. History of MPS, examination demonstrating trigger points 3. Fibromyalgia or other generalized pain condition 4. Opioid use 5. Active mood or substance use disorder 6. Taking or unable to wean off pain medications that directly affect neuronal or muscle excitability at least 2 weeks prior to study enrollment and remain off for the duration of the study: gabapentin, pregabalin, topiramate, carbamazepine, oxcarbazepine, valproic acid, tricyclic antidepressants (such as nortriptyline and amitriptyline), tizanidine, cyclobenzaprine, carisoprodol, methocarbamol, benzodiazepines 7. Skin allergy or sensitivity that would preclude85 the use of adhesive electrodes 8. Systemic or psychiatric illness that in the opinion of the Site Investigator would interfere with the individual's ability to participate in the trial.