Clinical Research Directory

Inclusion Criteria: * On exclusive enteral nutrition for at least 6 months * Exclusive enteral nutrition that is intended to be continued for at least 6 more months. * No XANTH supplementation in the last 6 months. * Able to sit up to allow visual examinations to be performed * Sufficient understanding to perform visual examinations, at the discretion of the physician * Written consent signed by the patient or agreement of their carer, trusted person, relative, family for patients with cognitive impairment (assessed using an MMS test). A patient with an MMSE test result ≤ 24 will be considered as having cognitive disorders. Exclusion Criteria: * Current treatment with hydroxychloroquine or any other drug known to cause ocular toxicity * Visually impaired patient: patient unable to read text (font size 11) at close range, with visual correction if the patient usually wears it * Unoperated cataracts in both eyes * Pregnant or breastfeeding woman * Patient under legal protection: guardianship or curatorship * Participation in other research in the same field of dietary supplementation, which may interfere with the results of this research. Secondary exclusion criteria : * Absence of XANTH (lutein and zeaxanthin) deficiency\* in the blood sample taken at inclusion. * Physical, ophthalmological or cognitive characteristics, evaluated at the Quinze-Vingt ophthalmological examination, which do not allow a reliable measurement of MPOD or of all the settings of visual function.