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Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism
Sponsor: Bryan Cotton
Summary
The purpose of this study is to determine if additional interventions will assist with decreasing the risk and/or severity of thromboembolism (clotting complications) in patients who have experienced a major traumatic event.
Official title: Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism (TRAIT)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
314
Start Date
2023-09-27
Completion Date
2027-03
Last Updated
2025-05-14
Healthy Volunteers
No
Interventions
Thrombate infusion
Bolus intravenous infusion of Thrombate will be given to achieve antithrombin (AT) activity levels at 150% before the 3rd dose of Enoxaparin. The dose will be based on patient weight.
Placebo
Normal Saline will be given as one time IV before the 3rd dose of Enoxaparin. The dose will be based on patient weight.
Locations (4)
University of Colorado
Aurora, Colorado, United States
Jackson Memorial Hospital/University of Miami
Miami, Florida, United States
Vanderbilt University Hospital
Nashville, Tennessee, United States
The University of Texas Health Science Center at Houston
Houston, Texas, United States