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ACTIVE NOT RECRUITING
NCT05794906
PHASE3

A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer and Raise of Prostate Specific Antigen (PSA) Levels After Local Therapies

Sponsor: Bayer

View on ClinicalTrials.gov

Summary

Researchers are looking for a better way to treat men at high-risk of biochemical recurrence (BCR) of prostate cancer. BCR means that in men who had prostate cancer and were treated by either surgery and/ or radiation therapy, the blood level of a specific protein called PSA rises. PSA is a marker of prostate cancer cells activity. The PSA increase means that the cancer has come back even though conventional imaging such as computed tomography (CT) scans, magnetic resonance imaging (MRI) and bone scans does not show any lesion of prostate cancer. Recently a more sensitive imaging method called prostate-specific membrane antigen \[PSMA\] positron emission tomography \[PET\]) /computed tomography \[CT\]) scan may identify prostate cancer lesions not detectable by conventional imaging. Men with BCR have a higher risk of their cancer spreading to other parts of the body, particularly when PSA levels raised to a certain limit within a short period of time after local therapies. Once the cancer spreads to other parts of the body, it can become even harder to treat. In men with prostate cancer, male sex hormones (also called androgens) like testosterone can help the cancer grow and spread. To reduce androgens levels in these patients, there are treatments that block androgens production in the body called androgen deprivation therapy (ADT). ADT is often used to stop prostate cancer. Another way to stop prostate cancer growth and spread is to block the action of androgen receptors on prostate cancer cells called androgen receptor inhibitors (ARIs). The new generation ARIs including darolutamide can block the action of androgens receptors and are available for the treatment of prostate cancer in addition to ADT. It is already known that men with prostate cancer benefit from these treatments. The main objective of this study is to learn if the combination of darolutamide and ADT prolongs the time that the participants live without their cancer getting worse, or to death due to any cause, compared to placebo (which is a treatment that looks like a medicine but does not have any medicine in it) and ADT given for a pre-specified duration of 24 months. To do this, the study team will measure the time from the date of treatment allocation to the finding of new cancer spread in the participants by using PSMA PET/CT, or death due to any cause. The PSMA PET/CT scans is performed using a radioactive substance called a "tracer" that specifically binds to the prostate-specific membrane antigen (PSMA) which is a protein often found in large amounts on prostate cancer cells. To avoid bias in treatment, the study participants will be randomly (by chance) allocated to one of two treatment groups. Based on the allocated treatment group, the participants will either take darolutamide plus ADT or placebo plus ADT twice daily as tablets by mouth. The study will consist of a test (screening) phase, a treatment phase and a follow-up phase. The treatment duration is pre-specified to be 24 months unless the cancer gets worse, the participants have medical problems, or they leave the study for any reason. In addition, image guided radiotherapy (IGRT) or surgery is allowed and your doctor will explain the benefits and risks of this type of therapy. During the study, the study team will: * take blood and urine samples. * measure PSA and testosterone levels in the blood samples * do physical examinations * check the participants' overall health * examine heart health using electrocardiogram (ECG) * check vital signs * check cancer status using PSMA PET/CT scans, CT, MRI and bone scans * take tumor samples (if required) * ask the participants if they have medical problems About 30 days after the participants have taken their last treatment, the study doctors and their team will check the participants' health and if their cancer worsened. The study team will continue to check this and regularly ask the participants questions about medical problems and subsequent therapies until they leave the study for any reason or until they leave the study for any reason or until the end of the study, whatever comes first.

Official title: A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Darolutamide Plus Androgen Deprivation Therapy (ADT) Compared With Placebo Plus ADT in Patients With High-risk Biochemical Recurrence (BCR) of Prostate Cancer

Key Details

Gender

MALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

985

Start Date

2023-04-03

Completion Date

2030-03-29

Last Updated

2026-03-17

Healthy Volunteers

No

Interventions

DRUG

Darolutamide (BAY1841788, Nubeqa)

Coated tablet, 300 mg / tablet, oral.

OTHER

Placebo matching darolutamide

Coated tablet, oral

OTHER

ADT

Luteinizing hormone-releasing hormone \[LHRH\] agonist/antagonists

Locations (228)

Mayo Clinic Hospital - Phoenix - Cardiology

Phoenix, Arizona, United States

City of Hope - Duarte Cancer Center

Duarte, California, United States

USC Norris Comprehensive Cancer Center

Los Angeles, California, United States

Tower Urology

Los Angeles, California, United States

UCLA Clark Urology Center

Los Angeles, California, United States

UCSF Bakar Precision Cancer Medicine Building - Genitourinary

San Francisco, California, United States

Colorado Urology - St. Anthony Hospital Campus

Lakewood, Colorado, United States

Northwestern Medicine - Urology

Chicago, Illinois, United States

The University of Kansas Cancer Center - Richard and Annette Bloch Radiation Oncology Pavilion

Kansas City, Kansas, United States

Chesapeake Urology Associates - Towson

Baltimore, Maryland, United States

Sidney Kimmel Comprehensive Cancer Center - Johns Hopkins

Baltimore, Maryland, United States

Dana-Farber Cancer Institute - Oncology Department

Boston, Massachusetts, United States

Barbara Ann Karmanos Cancer Institute - Detroit Headquarters

Detroit, Michigan, United States

M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center

Minneapolis, Minnesota, United States

Washington University School of Medicine - Center for Advanced Medicine (CAM)

St Louis, Missouri, United States

XCancer Omaha

Omaha, Nebraska, United States

NYU Langone Health

Mineola, New York, United States

Icahn School of Medicine at Mount Sinai - Oncology

New York, New York, United States

Alliance Urology Specialists

Greensboro, North Carolina, United States

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

Carolina Urological Research Center

Myrtle Beach, South Carolina, United States

University Hospital Simmons Cancer Center Genitourinary Clinic

Dallas, Texas, United States

The University of Texas MD Anderson Cancer Center - Texas Medical Center

Houston, Texas, United States

USA Clinical Trials

San Antonio, Texas, United States

The Urology Place

San Antonio, Texas, United States

Chris O'Brien Lifehouse

Camperdown, New South Wales, Australia

Northern Hospital

Epping, New South Wales, Australia

University of New South Wales (UNSW) - Liverpool Hospital - Liverpool Cancer Therapy Centre

Liverpool, New South Wales, Australia

Sydney Adventist Hospital

Wahroonga, New South Wales, Australia

Royal Adelaide Hospital

Adelaide, South Australia, Australia

Eastern Clinical Research Unit - Box Hill

Box Hill, Victoria, Australia

Epworth HealthCare

East Melbourne, Victoria, Australia

Barwon Health

Geelong, Victoria, Australia

Austin Health

Heidelberg, Victoria, Australia

Western Urology

Maribyrnong, Victoria, Australia

Sir Charles Gairdner Hospital

Nedlands, Western Australia, Australia

Medizinische Universitaet Graz - Klinische Abteilung für Onkologie - Innere Medizin

Salzburg, Styria, Austria

Medizinische Universität Innsbruck

Innsbruck, Tyrol, Austria

Ordensklinikum Linz GmbH Elisabethinen

Linz, Upper Austria, Austria

Krankenhaus der Barmherzigen Brüder

Vienna, Upper Austria, Austria

Medizinische Universität Wien- Universitätsklinik für Urologie

Vienna, Vienna, Austria

Uniklinikum Salzburg - Landeskrankenhaus

Vienna, Vienna, Austria

Maria Middelares General Hospital | Medical Oncology Department

Ghent, Belgium

UZ Gent - department Urology

Ghent, Belgium

Jessa Hospital | Campus Virga Jesse - Data Management Oncology and Hematology Department

Hasselt, Belgium

AZ Groeninge Campus Kennedylaan - Urology

Kortrijk, Belgium

Hopital de La Louvière - Site Jolimont - Oncology department

La Louvière, Belgium

Universitair Ziekenhuis Leuven | Gasthuisberg Campus - Urology Department

Leuven, Belgium

Oncocentro - Fortaleza

Fortaleza, Ceará, Brazil

Hospital Evangélico de Cachoeiro de Itapemirim

Vitória, Espírito Santo, Brazil

Assistência Multidisciplinar em Oncologia (AMO)

Salvador, Estado de Bahia, Brazil

Hospital Moinhos de Vento-Centro Clínico

Uberlândia, Minas Gerais, Brazil

Liga Paranaense de Combate ao Cancer-Hosp Erasto Gaertner

Curitiba, Paraná, Brazil

Liga Norte Riograndense Contra o Cancer | Centro de Pesquisa Clínica

Natal, Rio Grande do Norte, Brazil

Hospital Mae de Deus

Porto Alegre, Rio Grande do Sul, Brazil

Faculdade de Medicina do ABC

Santo André, São Paulo, Brazil

Instituto do Cancer do Estado de Sao Paulo

São Paulo, São Paulo, Brazil

Hospital Sirio Libanes

São Paulo, São Paulo, Brazil

Real e Benemérita Associação Portuguesa de Beneficência

São Paulo, São Paulo, Brazil

Hospital Alemao Oswaldo Cruz

São Paulo, São Paulo, Brazil

Hospital do Cancer de Sao Paulo - A. C. Camargo

São Paulo, São Paulo, Brazil

Inst. de Assistência Médica ao Sérvidor Público Estadual

São Paulo, São Paulo, Brazil

Hospital das Clínicas da Universidade de Campinas - UNICAMP

São Paulo, São Paulo, Brazil

Hospital São Rafael

São Paulo, São Paulo, Brazil

Universidade Estadual do Rio de Janeiro

Rio de Janeiro, Brazil

Instituto D'Or Pesquisa e Ensino (IDOR) (D'Or Institute for Research & Education) - Rio de Janeiro

Rio de Janeiro, Brazil

Prostate Cancer Centre

Calgary, Alberta, Canada

Kaye Edmonton Clinic - Dianne and Irving Kipnes Urology Centre

Edmonton, Alberta, Canada

BC Cancer | Abbotsford

Abbotsford British Columbia, British Columbia, Canada

Vancouver Prostate Centre

Vancouver, British Columbia, Canada

BC Cancer | Victoria

Victoria, British Columbia, Canada

Nova Scotia Health Authority

Halifax, Nova Scotia, Canada

St. Joseph's Healthcare - Hamilton

Hamilton, Ontario, Canada

London Health Sciences Centre (LHSC) - London Regional Cancer Program (LRCP)

London, Ontario, Canada

Princess Margaret Cancer Centre - Oncology Department

Toronto, Ontario, Canada

Hôtel-Dieu de Lévis - Urology

Québec, Province, Canada

CISSS de l'Outaouais - Hopital de Gatineau - Centre de cancerolgie

Gatineau, Quebec, Canada

Urology South Shore Research - Research Department

Greenfield Park, Quebec, Canada

Hopital Maisonneuve-Rosemont

Montreal, Quebec, Canada

Sir Mortimer B. Davis Jewish General Hospital - Radiation Oncology

Montreal, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke (CHUS) - Hopital Fleurimont

Sherbrooke, Quebec, Canada

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-Centre-du-Quebec - Radio-oncologie

Trois-Rivières, Quebec, Canada

Peking University First Hospital - Oncology Department

Beijing, Beijing Municipality, China

Zhongnan hospital ,Wuhan University

Wuhan, Hubei, China

Hunan Cancer Hospital - Oncology Department

Changsha, Hunan, China

Nanjing First Hospital

Nanjing, Jiangsu, China

Fudan University Shanghai Cancer Center - Oncology Department

Shanghai, Jiangsu, China

West China Hospital,Sichuan University

Chengdu, Sichuan, China

The 1st Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

Peking Union Medical College Hospital (PUMCH) - East Location

Beijing, China

Jiangsu Provincial People's Hospital - The First Affiliated Hospital of Nanjing Medical University

Nanjing, China

Tianjin Cancer Hospital, Airport Hospital

Tianjin, China

Fakultni nemocnice u Sv. Anny, Onkologicko-chirurgicke oddeleni

Brno, Czechia

Masarykova Univerzita - Masarykuv Onkologicky Ustav (MOU) - Klinika Komplexni Onkologicke Pece (KKOP)

Brno, Czechia

Fakultní nemocnice Olomouc - Onkologická klinika

Olomouc, Czechia

Všeobecná fakultní nemocnice v Praze - Urologická klinika

Prague, Czechia

Thomayerova Nemocnice (TN) (Thomayers Hospital) - Onkologicka Klinika 1. LF UK A TN

Prague, Czechia

Fakultní nemocnice Motol a Homolka, Pracovište MOTOL - Onkologická klinika 2. LF UK a FNMH

Prague, Czechia

Aarhus Universitetshospital

Aarhus N, Central Jutland, Denmark

Aalborg University Hospital

Aalborg, North Denmark, Denmark

Sjællands University hospital Næstved

Næstved, Region Sjælland, Denmark

Rigshospitalet - Kræftbehandling

København Ø, Denmark

Oulu University Hospital, Oulun yliopistollinen sairaala (OYS)

Oulu, North Ostrobothnia, Finland

Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS)

Tampere, Pirkanmaa, Finland

Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Urologia

Turku, Southwest Finland, Finland

HUS-Yhtymä, Helsingin yliopistollinen sairaala (HUS) - Urologia

Helsinki, Uusimaa, Finland

Centre Hospitalier Universitaire de Clermont Ferrand - Gabriel Montpied - Service Urologie

Clermont-Ferrand, Auvergne-Rhône-Alpes, France

Center Hospitalier Michallon - Grenoble - Service d Urologie et de la transplantation Renale

La Tronche, Auvergne-Rhône-Alpes, France

UNICANCER - Centre Leon-Berard (CLB) - Medical oncology

Lyon, Auvergne-Rhône-Alpes, France

HCL - Centre Hospitalier Lyon Sud

Pierre-Bénite, Auvergne-Rhône-Alpes, France

CHRU Besancon - Hopital Jean Minjoz

Besançon, Bourgogne-Franche-Comté, France

Institut de cancerologie de Bourgogne - Departement radiotherapie

Dijon, Bourgogne-Franche-Comté, France

Centre Georges Francois Leclerc Dijon - service de radiotherapie

Dijon, Bourgogne-Franche-Comté, France

Hopital La Cavale Blanche - CHU de Brest - institut de cancerologie et d'imagerie

Brest, Brittany Region, France

CHU Rennes - Hopital Pontchaillou

Rennes, Brittany Region, France

Institut de Cancerologie Jean Godinot - Departement oncologie medicale

Reims, Grand Est, France

ICANS - Institut de Cancerologie de Strasbourg Europe

Strasbourg, Grand Est, France

Institut de Cancérologie de Lorraine - Alexis Vautrin

Vandœuvre-lès-Nancy, Grand Est, France

Hopital Claude Huriez - Lille - Urologie

Lille, Hauts-de-France, France

Hopital Prive Le Bois - Centre Bourgogne - Service radiotherapie oncologie

Lille, Hauts-de-France, France

Centre d' Oncologie du Pays Basque Clinique Belharra - Bayonne - Oncologie medicale

Bayonne, Nouvelle-Aquitaine, France

CHU Bordeaux - Hopital Pellegrin - Service urologie

Bordeaux, Nouvelle-Aquitaine, France

Clinique Clementville

Montpellier, Occitanie, France

Institut Claudius Regaud - iUCT Oncopole - Service oncologie

Toulouse, Occitanie, France

Institut de Cancerologie de l'Ouest - Saint Herblain - Unite de therapie precoce

Saint-Herblain, Pays de la Loire Region, France

AP-HM - Hopital de la Timone

Marseille, Provence-Alpes-Côte d'Azur Region, France

APHP - Hopital Henri Mondor - Departement Urologie

Créteil, Île-de-France Region, France

Institut Curie - Saint-Cloud

Saint-Cloud, Île-de-France Region, France

Gustave Roussy - Departement Oncologie-Radiotherapie

Villejuif, Île-de-France Region, France

Klinikum Mannheim GmbH

Mannheim, Baden-Wurttemberg, Germany

Studienpraxis Urologie

Nürtingen, Baden-Wurttemberg, Germany

Universitätsklinikum Würzburg

Würzburg, Bavaria, Germany

Universitätsklinikum der Johann Wolfgang Goethe Universität

Frankfurt am Main, Hesse, Germany

Städtisches Klinikum Braunschweig GmbH

Braunschweig, Lower Saxony, Germany

Universitätsmedizin der Georg-August-Universität Göttingen

Göttingen, Lower Saxony, Germany

Urologicum Duisburg

Duisburg, North Rhine-Westphalia, Germany

Marienhospital Herne Universitätsklinik

Herne, North Rhine-Westphalia, Germany

Universitätsklinikum Münster

Münster, North Rhine-Westphalia, Germany

Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden

Dresden, Saxony, Germany

Medizinische Fakultät der Otto-von-Guericke Universität

Magdeburg, Saxony-Anhalt, Germany

Universitätsklinikum Aachen / Klinik und Poliklinik für Urologie und Kinderurologie

Aachen, Germany

Marien-Krankenhaus Bergisch Gladbach

Bergisch Gladbach, Germany

Vivantes Klinikum Am Urban

Berlin, Germany

Universitätsklinikum Hamburg-Eppendorf - Martini-Klinik am UKE GmbH

Hamburg, Germany

Universitaetsklinikum Jena - Klinik fuer Urologie

Jena, Germany

Universitätsklinikum Schleswig-Holstein/ Klinik für Urologie

Kiel, Germany

Johannes Gutenberg-Universität Mainz - Urologie

Mainz, Germany

Klinikum Stuttgart / Klinik für Urologie und Transplantationschirurgie

Stuttgart, Germany

Urologische Gemeinschaftspraxis Wesel

Wesel, Germany

Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Urologiai Klinika

Budapest, Hungary

Orszagos Onkologiai Intezet

Budapest, Hungary

Budapesti Uzsoki Utcai Kórház

Budapest, Hungary

Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet

Budapest, Hungary

Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz

Győr, Hungary

Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz

Nyíregyháza, Hungary

Azienda Ospedaliero Universitaria Ospedali Riuniti_Foggia - Oncologia Medica e Terapia Biomolecolare Universitaria

Foggia, Apulia, Italy

IRCCS Istituto Nazionale Tumori Fondazione Pascale - S. C. Oncologia Clinica Sperimentale Uro-Ginecologica

Naples, Campania, Italy

Azienda Unita Sanitaria Locale Di Bologna_Ospedale Bellaria - Oncologia Medica

Bologna, Emilia-Romagma, Italy

Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Urologia

Bologna, Emilia-Romagna, Italy

Azienda Ospedaliero Universitaria di Modena_Policlinico - Oncologia

Modena, Emilia-Romagna, Italy

Azienda USL IRCCS di Reggio Emilia_Arcispedale Santa Maria Nuova - S.C. Oncologia Provinciale

Reggio Emilia, Emilia-Romagna, Italy

Centro di Riferimento Oncologico di Aviano - Oncologia Radioterapica

Aviano, Friuli Venezia Giulia, Italy

I.F.O. Istituti Fisioterapici Ospitalieri_Ospedale Regina Elena - Urologia

Rome, Lazio, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Degenza di Radioterapia Oncologica

Rome, Lazio, Italy

IRCCS Ospedale Policlinico San Martino - Oncologia Medica 1

Genoa, Liguria, Italy

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Oncologia

Bergamo, Lombardy, Italy

Ospedale San Raffaele s.r.l - Urologia

Milan, Lombardy, Italy

Humanitas Mirasole S.p.A. - Oncologia Medica ed Ematologia

Rozzano, Lombardy, Italy

A.O.U. Città della Salute e della Scienza di Torino_Molinette - Urologia U

Turin, Piedmont, Italy

Azienda Provinciale Per I Servizi Sanitari_Ospedale Santa Chiara - UO Oncologia Medica

Trento, Trentino-Alto Adige, Italy

A.O. di Perugia_Hospital Santa Maria della Misericordia - S.C. Radioterapia Oncologica

Perugia, Umbria, Italy

Istituto Oncologico Veneto_Castelfranco Veneto - UOC Urologia Oncologica

Castelfranco Veneto, Veneto, Italy

Azienda Ospedaliera Policlinico Universitario Tor Vergata - UOC Radioterapia

Roma, Veneto, Italy

Cliniche Gavazzeni S.p.A - Dipartimento Area Chirurgia Unità Operativa di Urologia

Bergamo, Italy

Azienda Ospedaliera Santa Croce e Carle - Oncologia

Cuneo, Italy

Hokkaido University Hospital

Sapporo, Hokkaido, Japan

Kanazawa University Hospital

Kanazawa, Ishikawa-ken, Japan

Yokohama City University Hospital

Yokohama, Kanagawa, Japan

The University of Osaka Hospital

Suita, Osaka, Japan

Institute of Science Tokyo Hospital

Bunkyo-ku, Tokyo, Japan

Kyoto University Hospital

Kyoto, Japan

Tergooi MC | Hilversum - Wetenschapsbureau

Hilversum, North Holland, Netherlands

Albert Schweitzer Hospital | Internal Medicine - Oncology Department

Dordrecht, South Holland, Netherlands

St. Franciscus Gasthuis

Rotterdam, South Holland, Netherlands

HagaZiekenhuis van Den Haag

The Hague, South Holland, Netherlands

St. Antonius Ziekenhuis | Utrecht - R&D Interne Geneeskunde

Nieuwegein, Utrecht, Netherlands

University Medical Center Groningen | Urology Department

Groningen, Netherlands

Tauranga Urology Research Limited

Tauranga, Bay of Plenty, New Zealand

Canterbury Urology Research Trust

Christchurch, Canterbury, New Zealand

MidCentral District Health Board (MDHB) - Palmerston North Hospital (PNH)

Palmerston North, Manawatu-Wanganui, New Zealand

Auckland City Hospital

Auckland, New Zealand

Centrum Onkologii im. Prof. Franciszka Lukaszczyka

Bydgoszcz, Poland

Swietokrzyskie Centrum Onkologii

Kielce, Poland

Centrum Medyczne iMed24

Krakow, Poland

Medrise Sp. z o.o. Centrum Badan Klinicznych

Lublin, Poland

Szpital Grochowski im. dr.med. Rafala Masztaka

Warsaw, Poland

EMC Instytut Medyczny SA - Penta Hospitals Przychodnie, Wroclaw Wejherowska

Wroclaw, Poland

Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Urologia

Coimbra, Portugal

Instituto Portugues de Oncologia de Lisboa | Unidade de Investigacao Clinica - Departamento de Urologia

Lisbon, Portugal

Companhia Uniao Fabril | Hospital CUF Tejo - Academic Center - Research Center

Lisbon, Portugal

Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica

Lisbon, Portugal

Hospital Santa Maria | Centro de Investigacao Clinica

Lisbon, Portugal

Complexo Hospitalario Universitario De Santiago | Oncologia Radioterapica

Santiago de Compostela, A Coruña, Spain

Hospital Universitario Marques De Valdecilla - Urologia

Santander, Cantabria, Spain

Hospital del Mar I Urologia

Barcelona, Spain

Fundacio Puigvert | Urologia

Barcelona, Spain

Hospital Universitari Vall D Hebron | Oncologia Radioterapica

Barcelona, Spain

Hospital Clinic De Barcelona | Urologia

Barcelona, Spain

Hospital Universitario Puerta Del Mar | Urologia

Cadiz, Spain

MD Anderson Cancer Center | Oncologia Radioterapica

Madrid, Spain

Hospital Universitario Ramon Y Cajal | Oncologia Radioterapica

Madrid, Spain

Hospital Universitario Hm Sanchinarro | Oncologia

Madrid, Spain

Hospital Universitario Virgen De La Victoria | Urologia

Málaga, Spain

Hospital General Universitario Morales Meseguer | Urologia

Murcia, Spain

Hospital Universitario Virgen Del Rocio S.L. | Urologia

Seville, Spain

Fundacion Instituto Valenciano De Oncologia | Urologia

Valencia, Spain

Hospital Universitario Y Politecnico La Fe | Oncologia Radioterapica

Valencia, Spain

Skane University Hospital - Department of Urology

Malmo, Skåne County, Sweden

Goteborgs Universitet

Gothenburg, Västra Götaland County, Sweden

Tungs' Taichung MetroHarbor Hospital

Taichung, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Koo Foundation Sun Yet-Sen Cancer Centre

Taipei, Taiwan

Chang Gung Memorial Hospital at Linkou

Taoyuan District, Taiwan

University College London Hospitals NHS Foundation Trust | University College Hospital (UCLH) - Cancer Clinical Trials Unit

London, Greater London, United Kingdom

The Royal Marsden NHS Foundation Trust | The Royal Marsden Hospital - The Royal Marsden Clinical Trials Unit (CTU)

London, Greater London, United Kingdom

Imperial College Healthcare NHS Trust | Charing Cross Hospital - Cancer Services

London, Greater London, United Kingdom

East and North Hertfordshire NHS Trust - Mount Vernon Hospital - Mount Vernon Cancer Centre (MVCC)

Northwood, Middlesex, United Kingdom

Royal Surrey NHS Foundation Trust | Royal Surrey County Hospital - Cancer Centre

Guildford, Surrey, United Kingdom