Clinical Research Directory

Inclusion Criteria: * Men and women ages 18+ * Current DSM-5 diagnosis of trichotillomania (TTM) or skin picking disorder (SPD) * Ability to understand and sign the consent form * Stable dose of medications for at least the past 3 months Exclusion Criteria: * Unstable medical illness based on history or clinically significant abnormalities on baseline physical examination * Current pregnancy or lactation, or inadequate contraception in women of childbearing potential * Subjects considered an immediate suicide risk based on the Columbia Suicide Severity rating Scale (C-SSRS) * Past 12-month DSM-5 diagnosis of psychosis, bipolar disorder, mania, or a substance or alcohol use disorder * Illegal substance use based on urine toxicology screening * Previous treatment with memantine * Previous trial of ComB or similar BT protocol (e,g., habit reversal training) * Cognitive impairment that interferes with the capacity to understand and self-administer medication or provide written informed consent