Inclusion Criteria:
* 18 years or older.
* Histological confirmation of RCC with clear cell histology, including participants who may also have sarcomatoid features.
* Advanced (not amenable to curative surgery or radiation) or metastatic disease (American Joint Committee on Cancer \[AJCC\] stage IV)
* No prior systemic therapy for RCC with the following exception: one prior adjuvant or neoadjuvant therapy for fully resectable RCC if such therapy did not contain an agent targeting vascular endothelial growth factor (VEGF) or VEGF receptors and if at least 6 months after The last dose of adjuvant or neoadjuvant treatment has occurred.
* Karnofsky status score (KPS) 70%
* Measurable disease according to RECIST v1.1 according to the researcher
* Participants with favorable, moderate, and poor risk categories will be eligible for the study.
* Participants had to be stratified according to the International Metastatic RCC Database Consortium (IMDC) criteria according to favorable versus moderate versus poor risk status.
* Adequate hematologic and organ function, based on meeting all laboratory criteria within 14 days prior to the first dose of study treatment
* Patients who are willing and able to provide informed consent/written consent for the trial.
* Sexually active fertile patients and their partners must agree to use highly effective methods of contraception that alone or in combination with consistent and correct use during the study and for 5 months after the last dose of study treatment result in a lower failure rate. from 1% per year. An additional method of contraception, such as a barrier method (such as a condom), is recommended.
* A negative pregnancy test (urine or serum beta-human chorionic gonadotropin \[β-hCG\]) in screening sexually active women of childbearing potential.
Exclusion Criteria:
* Women who are pregnant, lactating, or planning to become pregnant within 3 months after the last dose of study drug and men who plan to father a child while enrolled in this study or within 5 months after the last dose of study drug.
* Any active central nervous system (CNS) metastases. Participants with treated and stable CNS metastases for at least one month were eligible.
* Any tumor that invades the superior vena cava (SVC), other major blood vessels, or the gastrointestinal tract. Any evidence of intratracheal or intrabronchial tumor
* Prior systemic therapy with VEGF, MET, AXL, KIT, or RET targeted therapy (including, but not limited to, sunitinib, pazopanib, axitinib, tivozanib, sorafenib, lenvatinib, bevacizumab, and cabozantinib)
* Prior treatment with anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137 or anti-CTLA-4 antibody, or any other antibody or drug that specifically co-stimulates T cells or Targets checkpoint routes.
* History of autoimmune disease requiring systemic therapy (eg, using disease-modifying agents, corticosteroids, or immunosuppressive drugs) within the past 2 years.
* Diagnosis of immunodeficiency or receipt of systemic steroid or any other form of immunosuppressive therapy within two weeks prior to the first dose of trial therapy.
* Administration of a live, attenuated vaccine within 30 days before the first dose of study treatment.
* The patient has an uncontrolled or significant intercurrent disease
* Hematuria, hematemesis, or hemoptysis of more than 0.5 teaspoons (2.5 mL) of clinically significant red blood, or other histories of significant bleeding (eg, pulmonary hemorrhage) in the 12 weeks before the first dose.
* Cavity lung lesions or known manifestations of endobronchial disease.
* The lesion invades a major blood vessel including, but not limited to, the inferior vena cava, pulmonary artery, or aorta.
* Known psychiatric or substance abuse disorders that interfere with compliance with trial requirements.
* History or current evidence of any condition, treatment, or laboratory abnormality that may confound the results of the trial, interfere with the patient's participation throughout the trial, or in the opinion of the treating investigator is not in the patient's best interest for participation.
* The participant is currently participating in a study of another investigational agent and has received study treatment or used an investigational device within 4 weeks prior to the first dose of treatment.
* Allergy or previous hypersensitivity to the components of the studied therapeutic formulation has been identified. Patients with a history of infusion-related reactions to prior therapy may be eligible with sponsor approval if the reaction is considered mild and manageable with appropriate supportive care (eg, use of prodrugs per standard of care).
* Individuals with evidence of active malignancy other than RCC (except for curable early-stage cancer such as resected skin cancers and/or completely resected prostate cancer).
