Clinical Research Directory

Inclusion Criteria: * Hong Kong Chinese adults aged 18-years-old to 65-years-old; * diagnosed with moderate level of depression (a score of 10\~20), evaluated by the Patient Health Questionnaire-9 (PHQ-9); * can communicate in spoken Cantonese and written Chinese; * willing to provide written informed consent and be able to adhere to the study protocol. Exclusion Criteria: * being pregnant or during the lactation, or plan to get pregnant; * new onset or change of antidepressant medication or dosage in the last 3 months; * PHQ-9 score≥20, meaning a severe level of depression; * with a previous or present diagnosis of psychotic disorders as screened by the Chinese version of the Structured Clinical Interview for DSM-IV; * the score of Hong Kong Montreal Cognitive Assessment less than 22; * significant suicidal risk as rated by the Hamilton Depression Rating Scale item on suicide (score ≥3); * with diagnosis of illness which can interfere the individuals to participate or adhere to the modified lifestyle; * with diagnosis of medical conditions, which are not suitable to modify diet or do physical activities recommended by physicians; * joining in another clinical trial during the study period; * with any major medical condition that causes depression based on the judgement of the investigator.