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Addressing Asymptomatic Plasmodium Reservoirs to Accelerate Malaria Elimination and Eradication in Rwanda.
Sponsor: King Faisal Hospital Rwanda
Summary
The investigators believe that to effectively achieve malaria elimination in Rwanda, it is critical to target the human reservoirs of Plasmodium falciparum using local and readily available Artemisia tea. Asymptomatic infections detectable by PCR are important reservoirs because they often persist for months and harbor gametocytes, the parasite stage infectious to mosquitoes. Lessons learnt from this study will be of critical importance for health decision makers with regard to potential malaria control. MSc and PhD students will be trained and the impact of this research project will be enormous on the socioeconomic transformation of Rwanda.
Official title: Addressing Both Naturally Occurring and ACT-induced Plasmodium Reservoirs Using Artemisia Infusions to Accelerate Malaria Elimination and Eradication in Rwanda: A Proof of Concept Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
125
Start Date
2024-03-01
Completion Date
2026-12-31
Last Updated
2023-10-17
Healthy Volunteers
Yes
Conditions
Interventions
Artemisia afra or Annua 10g oral infusion/tea per day for 14 days
Participants will be recruited after completing standard malaria treatment, and those who have a positive qRT-PCR for plasmodium gametocyte reservoirs will be randomly assigned to either artemisia afra tea, or artemisia annua tea or into the control group with no intervention