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Modulating Goal-directed Navigation Using Noninvasive Brain Stimulation
Sponsor: Rutgers, The State University of New Jersey
Summary
Our specific aim is to examine the effects of TMS on spatial processing during goal-directed navigation. In these experiments the investigators will utilize a scalp-recorded brain oscillation called right posterior theta that is believed to index the sensitivity of the parahippocampal cortex to spatial context. Here the investigators will asked whether this electrophysiological signal can be modulated up or down using TMS while participants engage in virtual navigation tasks, and if so, whether it would affect the spatial encoding of rewards and subsequent choices during task performance.
Official title: Modulating Spatial Processing During Goal-directed Navigation Using Transcranial Magnetic Stimulation
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-03-24
Completion Date
2026-08-31
Last Updated
2025-11-17
Healthy Volunteers
Yes
Conditions
Interventions
Active 10-Hz TMS to the parietal cortex
The active 10-Hz TMS group will receive 10hz TMS stimulation in the first TMS session, and single pulse TMS in the second TMS session. Participants in the active stimulation group will receive 10-Hz TMS to right parietal cortex. The TMS target will be based on subject specific anatomical MRI images (diffusion imaging). TMS will be delivered using a robotic neuronavigation system (Smartmove, ANT). Stimulation intensity will be standardized at 110% of RMT and adjusted to the skull to cortical surface based on e-field calculations (simnibs). Stimulation will be delivered to the right parietal cortex using an active/placebo figure-8 coil, an magventure TMS device.
Active single pulse TMS to the parietal cortex
The active single pulse TMS group will receive single pulse TMS stimulation in the first and second TMS session. Participants in the active stimulation group will receive single pulse TMS to right parietal cortex. The TMS target will be based on subject specific anatomical MRI images (diffusion imaging). TMS will be delivered using a robotic neuronavigation system (Smartmove, ANT). Stimulation intensity will be standardized at 110% of RMT and adjusted to the skull to cortical surface based on e-field calculations (simnibs). Stimulation will be delivered to the right parietal cortex using an active/placebo figure-8 coil, an magventure TMS device.
Sham 10-Hz TMS to the right parietal cortex
The parameters in the active arms will be as above with the internal randomization of the device internally switching to sham in a blinded fashion.
Sham single-pulse rTMS the rigt parietal cortex
The parameters in the active arms will be as above with the internal randomization of the device internally switching to sham in a blinded fashion.
Locations (1)
Rutgers University - Newark
Newark, New Jersey, United States