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RECRUITING
NCT05807555

Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children

Sponsor: Centre Hospitalier Universitaire de Saint Etienne

View on ClinicalTrials.gov

Summary

The Autonomic Nervous System (ANS) regulates the inflammatory response in real time, just as it controls heart rate and other vital functions. Many studies have investigated induced stimulation of the vagus nerve and its therapeutic effect in inhibiting TNFα (Tumor Necrosis Factor alpha) secretion, and therefore the risk of hypotension, septic shock, organ dysfunction during inflammation. While the anti-inflammatory effect of the autonomic nervous system on inflammation has been well studied, conversely, the effect of major inflammation on the balance of the autonomic nervous system is more difficult to understand. The inflammatory reflex could be overwhelmed and the regulatory centers of the brainstem dysregulated during situations of extreme inflammation.

Official title: Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children - An Observational Study

Key Details

Gender

All

Age Range

1 Day - 17 Years

Study Type

OBSERVATIONAL

Enrollment

60

Start Date

2023-03-29

Completion Date

2025-01-01

Last Updated

2024-05-03

Healthy Volunteers

Yes

Interventions

OTHER

Ambulatory ECG

24h ECG monitoring

BIOLOGICAL

Blood sample

The usual biological tests necessary for the management of the child and the addition of 1 tube of 2 ml

Locations (1)

Chu de Saint-Etienne

Saint-Etienne, France