Clinical Research Directory

Inclusion Criteria: 1. Histopathologically or Cytologically confirmed newly diagnosed untreated DLBCL; 2. There is at least one radiographically measurable lesion (i.e., ≥ 15mm in diameter); 3. Age ≥ 70 years; 4. Life expectancy \>3 months; 5. Patients with proper organic function (alanine aminotransferase, bilirubin, creatinine \< 3 times the upper limit of normal; cardiac ejection fraction ≥ 50%; SPO2\>90% under non-oxygenated conditions). 6. Written informed consent obtained from the subject. Exclusion Criteria: 1. Patients with severe liver and kidney dysfunction (alanine aminotransferase, bilirubin, creatinine \> 3 times the upper limit of normal); 2. Patients with organic heart disease with clinical symptoms or cardiac dysfunction (NYHA grade ≥2); 3. Uncontrolled active infection; 4. Patients with central nervous system DLBCL; 5. A history of vascular embolism; 6. Co-existence of other tumors; 7. Systemic corticosteroid therapy is needed; 8. Any other psychological conditions that prevent patients from participating in the study or signing the informed consent form.