Clinical Research Directory

Inclusion Criteria * Men ≥18 years old under the care of an Active Surveillance clinic. * Known diagnosis of PrCa, deemed suitable for Active surveillance at multi-disciplinary meeting (MDT). * Men at genetically higher PrCa risk who are either: (1) Men of any ancestry with a positive family history of PrCa defined as: * Having a first degree relative (or second degree if through female line) with histologically or death certificate proven PrCa diagnosed at \<70 years * Having two relatives on the same side of the family with histologically or death certificate proven PrCa where at least one is diagnosed at \<70 years * Having three relatives on the same side of the family with histologically or death certificate proven PrCa diagnosed at any age Or (2) Men of Black African or Black African-Caribbean ancestry defined as: * Both parents and all 4 grandparents from that origin Or (3) Men of any ancestry with a pathogenic mutation in a gene thought to cause a higher risk of prostate cancer: (including BRCA1, BRCA2, ATM, PALB2, MLH1, MSH2, MSH6, CHEK2 and other DNA repair gene mutations as listed in appendix A) Or (4) Men of any ancestry with a high genetic risk (common and/or rare variants) for PrCa resulting in a RR of ≥2 of PrCa * Men of any ancestry with no known high risk genetic factors who have been diagnosed with low grade PrCa and deemed suitable for Active Surveillance at multi-disciplinary meeting (control group) as defined in the 4 criteria above. * Who performance status 0-2 * Absence of any psychological, familial, sociological, or geographical situation potentially hampering compliance with the study protocol and follow-up schedule. Exclusion Criteria * No PrCa diagnosis * PrCa diagnosis that is not deemed suitable for active surveillance at multi-disciplinary meeting * Any significant psychological conditions that may be worsened or exacerbated by participation in the study