Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
Sponsor: TScan Therapeutics, Inc.
Summary
TScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous T cells are engineered to express a T cell receptor that recognizes tumor-associated antigens presented on specific Human Leukocyte Antigen (HLA) molecules. The purpose of this screening study is to collect samples to conduct HLA genotyping, HLA Loss of Heterozygosity (LOH) assessment, and expression of Tumor-associated Antigens (TAA) testing. These results will be used to determine if participants meet the eligibility criteria for these parameters and could potentially be enrolled in a TScan clinical study.
Official title: Screening Study to Determine HLA Type, HLA Loss of Heterozygosity Status and Tumor Antigen Expression in Participants With Locally Advanced (Unresectable) or Metastatic Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1150
Start Date
2023-06-26
Completion Date
2027-01-14
Last Updated
2025-11-17
Healthy Volunteers
No
Conditions
Interventions
Tumor and HLA Profiling
HLA genotyping and tumor tissue profiling for certain tumor-associated antigens and HLA LOH.
Locations (21)
HonorHealth Research and Innovation Institute
Scottsdale, Arizona, United States
University of California San Diego
San Diego, California, United States
Yale Cancer Center
New Haven, Connecticut, United States
Memorial Healthcare System
Hollywood, Florida, United States
University of Miami, Sylvester Comprehensive Cancer Center
Miami, Florida, United States
Orlando Health
Orlando, Florida, United States
University of South Florida
Tampa, Florida, United States
University of Chicago
Chicago, Illinois, United States
Norton Cancer Institute
Louisville, Kentucky, United States
Karmanos Cancer Institute
Detroit, Michigan, United States
University of Minnesota, Masonic Cancer Center
Minneapolis, Minnesota, United States
Columbia University Herbert Irving Comprehensive Cancer Center
New York, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Oncology Hematology Care
Cincinnati, Ohio, United States
The Cleveland Clinic
Cleveland, Ohio, United States
OU Health Stephenson Cancer Center
Oklahoma City, Oklahoma, United States
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States
Allegheny Hospitals Network
Pittsburgh, Pennsylvania, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
Sarah Cannon Research Institute
Nashville, Tennessee, United States
Baylor College of Medicine
Houston, Texas, United States