Clinical Research Directory
Browse clinical research sites, groups, and studies.
Interleaved TMS-fMRI in Ultra-treatment Resistant Depression
Sponsor: Sunnybrook Health Sciences Centre
Summary
This is a study that will recruit patients from the neurosurgery clinic and the regular TMS clinic. It's a smaller study designed to collect brain imaging pre-treatment and then use image guided TMS to treat patient with a one week "accelerated" rTMS protocol using the research TMS machine that is housed in Dr. Sean Nestor's lab. The idea is to examine whether severe treatment resistant depression has a different brain signature than less severe/TRD and whether the investigators can get a therapeutic response from patients that would otherwise undergo neurosurgery or will ultimately undergo neurosurgery.
Official title: Interleaved TMS-fMRI to Evaluate Intermittent Theta-burst and Dorsolateral Prefrontal Circuit Engagement in Ultra-treatment Resistant Depression
Key Details
Gender
All
Age Range
20 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2023-09-27
Completion Date
2025-07-07
Last Updated
2024-11-15
Healthy Volunteers
No
Conditions
Interventions
rTMS
Accelerated iTBS treatment
Locations (1)
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada