Clinical Research Directory
Browse clinical research sites, groups, and studies.
Parallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study)
Sponsor: Apnimed
Summary
This is a Phase 3 Randomized Double-Blind Placebo-Controlled 6-month Parallel-Arm Study to Compare a Fixed Dose Combination of AD109 to Placebo in Obstructive Sleep Apnea.
Official title: Phase 3 Randomized Double-Blind Placebo-Controlled 6-month Parallel-Arm Study to Compare a Fixed Dose Combination of Aroxybutynin/Atomoxetine (AD109) to Placebo in Obstructive Sleep Apnea (SynAIRgy Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
646
Start Date
2023-09-16
Completion Date
2025-03-14
Last Updated
2026-09-11
Healthy Volunteers
No
Conditions
Interventions
AD109
Aroxybutynin 2.5 mg/atomoxetine 75 mg tablet, administered orally once daily at bedtime (Weeks 2-26). Week 1 run-in: aroxybutynin 2.5 mg/atomoxetine 37.5 mg tablet.
Placebo
Matching placebo tablet administered orally once daily at bedtime for 26 weeks, with run-in and target dose matched to active arm packaging
Locations (73)
Alabama Neurology & Sleep Medicine
Tuscaloosa, Alabama, United States
Desert Clinical Research - CCT Research
Mesa, Arizona, United States
Foothills Research Center - CCT Research
Phoenix, Arizona, United States
Fiel Family Sports Medicine - PC CCT Research
Tempe, Arizona, United States
Noble Clinical Research
Tucson, Arizona, United States
Preferred Research Partners, Inc.
Little Rock, Arkansas, United States
Orange County Research Institute
Anaheim, California, United States
North County Neurology Associates
Carlsbad, California, United States
Core Healthcare Group
Cerritos, California, United States
Exalt Clinical Research
Chula Vista, California, United States
Catalina Research Institute
Montclair, California, United States
Probe Clinical Research Corporation
Riverside, California, United States
Pacific Research Network
San Diego, California, United States
Sleep Medicine Specialists of California
San Ramon, California, United States
SDS Clinical Trials Inc.
Santa Ana, California, United States
Provideré Research Inc.
West Covina, California, United States
Meris Clinical Research
Brandon, Florida, United States
Nouvelle Clinical Research
Cutler Bay, Florida, United States
Accel Research Sites
DeLand, Florida, United States
Research Centers of America, LLC
Hollywood, Florida, United States
Canvas Clinical Research
Lake Worth, Florida, United States
Florida Lung and Sleep Associates
Lehigh Acres, Florida, United States
Advanced Medical Research Institute
Miami, Florida, United States
Clinical Site Partners
Miami, Florida, United States
Clinical Neuroscience Solutions, Inc - Orlando
Orlando, Florida, United States
JSV Clinical Research Study Inc
Tampa, Florida, United States
Florida Pediatric Research Institute
Winter Park, Florida, United States
Atlanta Center for Medical Research, LLC
Atlanta, Georgia, United States
NeuroTrials Research
Atlanta, Georgia, United States
Georgia Neurology and Sleep Medicine Assoc
Suwanee, Georgia, United States
Javarra Inc-Privia Medical Group
Thomasville, Georgia, United States
St. Lukes Clinic - Idaho Pulmonary Associates
Meridian, Idaho, United States
Chicago Research Center Inc
Chicago, Illinois, United States
OSF HealthCare Saint Francis Medical Center
Peoria, Illinois, United States
The University of Kansas Medical Center
Kansas City, Kansas, United States
Advanced ENT and Allergy
Louisville, Kentucky, United States
Centennial Medical Group
Elkridge, Maryland, United States
Infinity Medical Research
North Dartmouth, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Revive Research Institute
Lathrup Village, Michigan, United States
Las Vegas Clinical Trials
North Las Vegas, Nevada, United States
Neurology Specialists of Monmouth County
West Long Branch, New Jersey, United States
Javara Inc - Tryon Medical Partners PLCC
Charlotte, North Carolina, United States
Research Carolina Elite
Denver, North Carolina, United States
Peters Medical Research, LLC
High Point, North Carolina, United States
PMG Research of Wilmington
Wilmington, North Carolina, United States
Lillestol Research LLC
Fargo, North Dakota, United States
CTI Clinical Research Center
Cincinnati, Ohio, United States
Sleep Management Institute (Intrepid)
Cincinnati, Ohio, United States
UC Health Sleep Medicine
Cincinnati, Ohio, United States
University Hospital of Cleveland Medical Center
Cleveland, Ohio, United States
Abington Neurological Associate
Abington, Pennsylvania, United States
Respiratory Specialists
Wyomissing, Pennsylvania, United States
Tribe Clinical Research LL
Greenville, South Carolina, United States
OnSite Clinical Solutions LLC/Carolina Cardiology Associates P.A
Rock Hill, South Carolina, United States
Chattanooga Research & Medicine, PLLC
Chattanooga, Tennessee, United States
FutureSearch Trials of Neurology
Austin, Texas, United States
FutureSearch Trials of Dallas, LP
Dallas, Texas, United States
The Heights Hospital (HD Heights)
Houston, Texas, United States
Weill Cornell Medical College
Houston, Texas, United States
Lone Star Lung and Sleep Clinic
Houston, Texas, United States
Huntsville Research Institute LLC
Huntsville, Texas, United States
Epic Medical Research
Red Oak, Texas, United States
Element Research Group
San Antonio, Texas, United States
South Ogden Family Medicine / CCT Research
South Ogden, Utah, United States
Canadian Sleep Consultants
Calgary, Alberta, Canada
Medical Arts Health Research
Kelowna, British Columbia, Canada
AMNDX
Markham, Ontario, Canada
West Ottawa Sleep Centre
Ottawa, Ontario, Canada
Canadian Phase Onward Inc.
Toronto, Ontario, Canada
Toronto Sleep Institute
Toronto, Ontario, Canada
Sleep and Alertness Center
Toronto, Ontario, Canada
McGill University Health Centre
Montreal, Quebec, Canada