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A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19
Sponsor: ModernaTX, Inc.
Summary
The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2).
Official title: A Randomized, Observer-Blind, Active-Controlled Phase 3 Study to Investigate the Safety, Immunogenicity, and Relative Vaccine Efficacy of mRNA-1283 Compared With mRNA-1273 in Participants Aged ≥12 Years for the Prevention of COVID-19
Key Details
Gender
All
Age Range
12 Years - Any
Study Type
INTERVENTIONAL
Enrollment
13553
Start Date
2023-03-28
Completion Date
2025-04-12
Last Updated
2026-05-01
Healthy Volunteers
Yes
Conditions
Interventions
mRNA-1283.222
Sterile liquid for injection
mRNA-1273.222
Sterile liquid for injection
mRNA-1283.815
Sterile liquid for injection
mRNA-1273.815
Sterile liquid for injection
Locations (230)
Optimal Research
Huntsville, Alabama, United States
Accel Research Sites- Achieve Clinical Research
Vestavia Hills, Alabama, United States
Chandler Clinical Trials
Chandler, Arizona, United States
Phoenix Clinical Research LLC
Phoenix, Arizona, United States
FRC - CCT Research
Phoenix, Arizona, United States
Headlands Research Sarasota
Scottsdale, Arizona, United States
Clinical Research Consortium
Tempe, Arizona, United States
Noble Clinical Research, LLC
Tucson, Arizona, United States
Del Sol research Management LLC.
Tucson, Arizona, United States
Lynn Institute of the Ozarks
Little Rock, Arkansas, United States
Anaheim Clinical Trials, LLC
Anaheim, California, United States
Velocity Clinical Research, Banning
Banning, California, United States
Velocity Clinical Research- Chula Vista
Chula Vista, California, United States
Benchmark Research
Colton, California, United States
Marvel Clinical Research 002, LLC
Huntington Beach, California, United States
Velocity Clinical Research Huntington Park
Huntington Park, California, United States
Velocity Clinical Research
La Mesa, California, United States
Chemidox Clinical Trials
Lancaster, California, United States
Long Beach Clinical Trials
Long Beach, California, United States
Velocity Clinical Research- Westlake
Los Angeles, California, United States
Velocity Clinical Research-North Hollywood
North Hollywood, California, United States
Empire Clinical Research
Pomona, California, United States
CenExel - CITrials
Riverside, California, United States
Artemis Institute for Clinical Research
Riverside, California, United States
Peninsula Research Associates
Rolling Hills Estates, California, United States
Benchmark Research
Sacramento, California, United States
Artemis Institute for Clinical Research
San Diego, California, United States
Acclaim Clinical Research
San Diego, California, United States
Lynn Institute of Denver
Aurora, Colorado, United States
Velocity Clinical Research Denver
Denver, Colorado, United States
Tekton Research - Fort Collins
Fort Collins, Colorado, United States
Tekton Research, Inc- Longmont Center
Longmont, Colorado, United States
Alliance for Multispeciality Research - Miami
Coral Gables, Florida, United States
Nature Coast Clinical Research
Crystal River, Florida, United States
Beautiful Minds Clinical Research Center
Cutler Bay, Florida, United States
Clinical Research Partners LLC
DeLand, Florida, United States
Hillcrest Medical Research, LLC
DeLand, Florida, United States
Velocity Clinical Research, Hallandale Beach
Hallandale, Florida, United States
Sweet Hope Research Specialty, Inc.
Hialeah, Florida, United States
CenExel Research Centers of America
Hollywood, Florida, United States
Nature Coast Clinical Research
Inverness, Florida, United States
Encore Research Group-Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Clinical Neuroscience Solutions, Inc
Jacksonville, Florida, United States
Health Awareness INC
Jupiter, Florida, United States
Accel Clinical Research
Lakeland, Florida, United States
Accel Research Sites
Largo, Florida, United States
Acclaim Clinical Research
Maitland, Florida, United States
Suncoast Research Group, LLC
Miami, Florida, United States
Clinical Trials of Florida
Miami, Florida, United States
Suncoast Research Associates, LLC
Miami, Florida, United States
Floridian Clinical Research
Miami Lakes, Florida, United States
Global Health Research Center, Inc.
Miami Lakes, Florida, United States
Clinical Neuroscience Solutions (CNS Healthcare site)
Orlando, Florida, United States
Headlands Research Orlando
Orlando, Florida, United States
Innovation Medical Research Center
Palmetto Bay, Florida, United States
Pines Care Research Center, Inc.
Pembroke Pines, Florida, United States
Suncoast Research Associates, LLC
Pembroke Pines, Florida, United States
Synexus
Pinellas Park, Florida, United States
Precision Clinical Research
Sunrise, Florida, United States
Global Health Research Center, Inc.
Tampa, Florida, United States
Santos Research Center CORP
Tampa, Florida, United States
Palm Beach Research Center
West Palm Beach, Florida, United States
Delricht Research
Atlanta, Georgia, United States
Atlanta Clinical Research Center
Atlanta, Georgia, United States
Baybol Research Institute
Chamblee, Georgia, United States
Centricity Research
Columbus, Georgia, United States
Elite Research Network
Decatur, Georgia, United States
Accel Research Sites Lake Oconee
Eatonton, Georgia, United States
Georgia Clinic, PC/CCT Research
Norcross, Georgia, United States
Clinical Research Atlanta/Headlands
Stockbridge, Georgia, United States
Velocity Clinical Research
Meridian, Idaho, United States
Chicago Clinical Research Institute
Chicago, Illinois, United States
Great Lakes Clinical Trials
Chicago, Illinois, United States
Velocity Clinical Research Valparaiso
Valparaiso, Indiana, United States
Alliance for Multispecialty Research, LLC
El Dorado, Kansas, United States
Johnson County Clin-Trials, Inc (JCCT)
Lenexa, Kansas, United States
Alliance for Multispecialty Research, LLC- Wichita
Wichita, Kansas, United States
Tekton Research Inc
Wichita, Kansas, United States
Alliance for Multispecialty Research-Lexington
Lexington, Kentucky, United States
Versailles Family Medicine
Versailles, Kentucky, United States
Meridian Clinical Research
Baton Rouge, Louisiana, United States
Benchmark Research
Covington, Louisiana, United States
MedPharmics
Covington, Louisiana, United States
Benchmark Research
Metairie, Louisiana, United States
Delricht Research
New Orleans, Louisiana, United States
Delricht Clinical Research
Prairieville, Louisiana, United States
Centennial Medical Group
Eldridge, Maryland, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
DM Clinical Research
Brookline, Massachusetts, United States
Great Lakes Research Institute
Southfield, Michigan, United States
Clinical Research Institute
Minneapolis, Minnesota, United States
Delricht Research
Gulfport, Mississippi, United States
The Center for Pharmaceutical Research
Kansas City, Missouri, United States
Delricht Research
Springfield, Missouri, United States
Sundance Clinical Research, LLC
St Louis, Missouri, United States
Delricht Research
Town and Country, Missouri, United States
Montana Medical Research, Inc
Missoula, Montana, United States
CCT research/ Methodist Physicians Clinic- Prairie Fields
Fremont, Nebraska, United States
Velocity Clinical Research
Grand Island, Nebraska, United States
Meridian Clinical Research, LLC
Lincoln, Nebraska, United States