Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Prevalence, Risk Factors and Optimal Biopsy Protocol of BE
Sponsor: E-DA Hospital
Summary
Detections of goblet cells and dysplasia are crucial for diagnosis and determining the surveillance program of Barrett's esophagus (BE). However, the optimal biopsy numbers and their yield rates of intestinal metaplasia (IM) and dysplasia are still uncertain, especially in Asia. The aim of this study was to determine the optimal biopsy protocol of BE.
Official title: The Prevalence, Risk Factors and Optimal Biopsy Protocol of Barrett's Esophagus in Taiwan - A Prospective Randomized Study
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
165
Start Date
2023-03-13
Completion Date
2026-12-31
Last Updated
2023-05-11
Healthy Volunteers
No
Conditions
Interventions
One biopsy
To do one biopsy at the proximal part of the longest columnar-lined esophagus.
Three biopsy
To do three biopsy at the proximal, middle and distal part of the longest columnar-lined esophagus.
Seattle protocol
To do 4-quadrant biopsy every 1-2 cm at the esophagogastric junction. Seattle protocol has been considered as the gold standard biopsy protocol for patients with suspected Barrett's Esophagus.
Endoscopy
The participants will receive meticulous endoscopic examination with narrow-band imaging.
Locations (1)
E-DA Hospital
Kaohsiung City, Taiwan