Clinical Research Directory

Inclusion Criteria: * Diagnosis of PCL (any histotype) defined as an extranodal lymphoma involving only the heart with possible involvement of the pericardium. * Age ≥18 years. * Diagnosis histologically confirmed. Cytofluorimetry analysis of pericardial fluid showing phenotypic features consistent with a primary cardiac lymphoma is permitted if a biopsy sample is not feasible/available for diagnosis; monoclonality is not accepted as a surrogate for diagnosis. * Date of diagnosis: from 1st January 2000 to 31st December 2020. * Only patients treated in first-line with chemoimmunotherapy regimens including an anti-CD20 monoclonal antibody are eligible for the study. * Signed written informed consent (in case of unreachable subject please see chapter 11.2) Exclusion Criteria: * Secondary cardiac involvement from lymphoma; primary mediastinal lymphoma with pericardial infiltration or other lymphomas with involvement of the pericardium/the heart by contiguity and primary effusion lymphoma are not included in this study. * Patients treated with chemotherapy regimens that did not include an anti-CD20 monoclonal antibody as first-line therapy. * Refuse to sign a written informed consent