Clinical Research Directory

Inclusion Criteria: 1. Advanced/unresectable or metastatic solid tumor with HER2 expression or mutation that is refractory to or intolerable with standard treatment, or for which no standard treatment is available; 2. At least one measurable lesion based on RECIST v1.1 criteria; 3. ECOG PS score: 0-1 points; 4. Expected survival period ≥ 3 months; 5. Adequate organ function; 6. Must take one medically approved contraceptive measure; 7. Patients voluntarily joined the study and signed informed consent. Exclusion Criteria: 1. Patients with known CNS metastasis or hepatic encephalopathy; 2. Suffering from peripheral neuropathy; 3. History of clinically significant lung diseases (e.g., interstitial pneumonia, pneumonitis, pulmonary fibrosis, and severe radiation pneumonitis) or suspected to have these diseases by imaging at screening period; 4. Patients with any active, known or suspected autoimmune disorder; 5. With known severe allergic reactions to any other monoclonal antibodies; 6. Patients with symptomatic ascites or pleural effusion requiring paracentesis and drainage, or patients who have undergone ascites or pleural effusion drainage within 2 weeks before the first dose; 7. Patients with other malignancies currently or within the past 5 years; 8. Uncontrolled cardiac diseases or symptoms; 9. With known hereditary or acquired bleeding (e.g., coagulopathy) or a tendency to clot (e.g., hemophiliacs); 10. Patients with other potential factors that may affect the study results.