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Cognitive Decline Following Deep Brain Stimulation
Sponsor: Medical University of South Carolina
Summary
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.
Official title: A Neural Basis for Cognitive Decline Following Deep Brain Stimulation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2023-04-01
Completion Date
2026-03-31
Last Updated
2025-04-29
Healthy Volunteers
Yes
Conditions
Interventions
Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
Participants in this study will already be undergoing a DBS intervention, however, this is part of their standard clinical care. Pre-surgical DBS candidates that enroll in this study will consent to participate in 1) pre-operative neuroimaging including a high-resolution MRI scan, 2) collection of pre-operative neurocognitive data via chart review and 3) a 1-year postoperative neurocognitive assessment.
Locations (1)
Medical University of South Carolina
Charleston, South Carolina, United States