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Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma
Sponsor: Lyell Immunopharma, Inc.
Summary
This is a Phase 1/2, multi-center, open-label study evaluating the safety and efficacy of rondecabtagene autoleucel (ronde-cel) also known as LYL314, a dual-targeting chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with aggressive large B-cell lymphoma.
Official title: A Phase 1/2 Multi-Center Study Evaluating the Safety and Efficacy of Rondecabtagene Autoleucel, a CD19/CD20 Dual-Targeting Chimeric Antigen Receptor T-Cell Therapy in Participants With Aggressive B-Cell Non-Hodgkin Lymphoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
270
Start Date
2023-05-09
Completion Date
2031-06-30
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
Rondecabtagene autoleucel (ronde-cel)
CAR T-cell therapy
Fludarabine
Conditioning chemotherapy
Cyclophosphamide
Conditioning chemotherapy
Locations (28)
University of California-Irvine Medical Center
Irvine, California, United States
Cedars-Sinai Medical Center
Los Angeles, California, United States
University of California, Los Angeles (UCLA) Medical Center
Los Angeles, California, United States
Scripps Clinic
San Diego, California, United States
Colorado Blood Cancer Institute
Denver, Colorado, United States
Augusta University Medical Center
Augusta, Georgia, United States
Indiana Blood and Marrow Transplantation
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
University of Louisville Brown Cancer Center
Louisville, Kentucky, United States
Louisiana State University Health Sciences Center
Shreveport, Louisiana, United States
Corewell Health
Grand Rapids, Michigan, United States
University of Nebraska Medical Center
Omaha, Nebraska, United States
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, United States
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States
University of Cincinnati (UC) Physicians Company, LLC
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Lehigh Valley Topper Cancer Center Institute
Allentown, Pennsylvania, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
West Penn Hospital
Pittsburgh, Pennsylvania, United States
Baylor University Medical Center
Dallas, Texas, United States
Texas Transplant Institute
San Antonio, Texas, United States
Huntsman Cancer Institute
Salt Lake City, Utah, United States
Intermountain Healthcare
Salt Lake City, Utah, United States
Virginia Oncology Associates
Norfolk, Virginia, United States
Virginia Commonwealth University-Massey Cancer Center
Richmond, Virginia, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States