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A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
Sponsor: Bristol-Myers Squibb
Summary
The purpose of this study is to compare the effectiveness of iberdomide maintenance to lenalidomide maintenance therapy after autologous stem cell transplantation (ASCT) in participants with newly diagnosed multiple myeloma (NDMM).
Official title: A Phase 3, Two-stage, Randomized, Multi-center, Controlled, Open-label Study Comparing Iberdomide Maintenance to Lenalidomide Maintenance Therapy After Autologous Stem Cell Transplantation (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) (EXCALIBER-Maintenance)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1230
Start Date
2023-06-22
Completion Date
2036-01-01
Last Updated
2026-09-17
Healthy Volunteers
No
Conditions
Interventions
Iberdomide
Specified dose on specified days
Lenalidomide
Specified dose on specified days
Locations (269)
Local Institution - 0202
Aurora, Colorado, United States
Local Institution - 0007
Jacksonville, Florida, United States
Local Institution - 0308
Tampa, Florida, United States
Local Institution - 0192
Tampa, Florida, United States
Local Institution - 0003
Weston, Florida, United States
Local Institution - 0019
Athens, Georgia, United States
Local Institution - 0018
Atlanta, Georgia, United States
Local Institution - 0021
Augusta, Georgia, United States
Local Institution - 0237
Chicago, Illinois, United States
University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion
Westwood, Kansas, United States
Local Institution - 0205
Clinton, Maryland, United States
Local Institution - 0279
Worcester, Massachusetts, United States
Local Institution - 0001
Ann Arbor, Michigan, United States
Local Institution - 0257
Detroit, Michigan, United States
Local Institution - 0296
Grand Rapids, Michigan, United States
Local Institution - 0303
Rochester, Minnesota, United States
Local Institution - 0207
Hattiesburg, Mississippi, United States
Local Institution - 0191
Morristown, New Jersey, United States
Local Institution - 0328
Brooklyn, New York, United States
Local Institution - 0288
Mineola, New York, United States
Local Institution - 0180
New York, New York, United States
Local Institution - 0020
New York, New York, United States
Local Institution - 0274
Westbury, New York, United States
Local Institution - 0331
Charlotte, North Carolina, United States
Local Institution - 0005
Charlotte, North Carolina, United States
Local Institution - 0281
Durham, North Carolina, United States
Local Institution - 0286
Winston-Salem, North Carolina, United States
Local Institution - 0322
Winston-Salem, North Carolina, United States
Local Institution - 0238
Cincinnati, Ohio, United States
Local Institution - 0299
Cleveland, Ohio, United States
Local Institution - 0002
Cleveland, Ohio, United States
Local Institution - 0017
Kansas, Ohio, United States
Local Institution - 0301
Mayfield Heights, Ohio, United States
Local Institution - 0013
Toledo, Ohio, United States
Local Institution - 0300
Wooster, Ohio, United States
Local Institution - 0203
Eugene, Oregon, United States
Local Institution - 0012
Philadelphia, Pennsylvania, United States
Local Institution - 0011
Philadelphia, Pennsylvania, United States
Local Institution - 0253
Pittsburgh, Pennsylvania, United States
Local Institution - 0294
Germantown, Tennessee, United States
Local Institution - 0004
Nashville, Tennessee, United States
Local Institution - 0193
Dallas, Texas, United States
Local Institution - 0009
Dallas, Texas, United States
Local Institution - 0006
Houston, Texas, United States
Local Institution - 0183
Ciudad Autonoma Buenos Aires, Buenos Aires F.D., Argentina
Local Institution - 0227
Ciudad Autonoma Buenos Aires, Buenos Aires F.D., Argentina
Local Institution - 0267
Pilar, B, Argentina
Local Institution - 0182
Córdoba, Argentina
Local Institution - 0088
Adelaide, South Australia, Australia
Local Institution - 0220
Box Hill, Victoria, Australia
Local Institution - 0078
Clayton, Victoria, Australia
Local Institution - 0244
Waratah, Australia
Local Institution - 0058
Linz, Austria
Local Institution - 0034
Sankt Pölten, Austria
Medizinische Universitaet Wien - Universitaetsklinik fuer Augenheilkunde und Optometrie
Vienna, Austria
Hanusch-Krankenhaus
Vienna, Austria
Local Institution - 0035
Charleroi, WHT, Belgium
Local Institution - 0048
Kortrijk, Belgium
Local Institution - 0214
Niterói, Rio de Janeiro, Brazil
Local Institution - 0082
Rio de Janeiro, Rio de Janeiro, Brazil
Local Institution - 0081
Ribeirão Preto, São Paulo, Brazil
Local Institution - 0277
São Paulo, São Paulo, Brazil
Local Institution - 0194
São Paulo, São Paulo, Brazil
Local Institution - 0241
São Paulo, São Paulo, Brazil
Local Institution - 0190
Barretos, Brazil
Local Institution - 0083
Porto Alegre, Brazil
Local Institution - 0096
Rio de Janeiro, Brazil
Local Institution - 0098
Salvador, Brazil
Local Institution - 0270
Edmonton, Alberta, Canada
Local Institution - 0208
Ottawa, Ontario, Canada
Local Institution - 0307
Montreal, Quebec, Canada
Local Institution - 0210
Québec, Quebec, Canada
Local Institution - 0186
Santiago, Chile
Local Institution - 0258
Temuco, Chile
Local Institution - 0099
Vitacura, Chile
Local Institution - 0196
Hefei, AH, China
Local Institution - 0229
Beijing, Beijing Municipality, China
Local Institution - 0326
Beijing, BJ, China
Local Institution - 0242
Chongqing, Chongqing Municipality, China
Local Institution - 0321
Chongqing, CQ, China
Local Institution - 0304
Guangzhou, GD, China
Local Institution - 0261
Guangzhou, Guangdong, China
Local Institution - 0256
Shenzhen, Guangdong, China
Local Institution - 0246
Zhengzhou, Henan, China
Local Institution - 0262
Changsha, HN, China
Local Institution - 0282
Changsha, HN, China
Local Institution - 0266
Nanjing, Jiangsu, China
Local Institution - 0239
Xuzhou, Jiangsu, China
Local Institution - 0263
Nanchang, Jiangxi, China
Local Institution - 0091
Changchun, JL, China
Local Institution - 0094
Shenyang, Liaoning, China
Local Institution - 0240
Jinan, SD, China
Local Institution - 0265
Xi'an, Shaanxi, China
Local Institution - 0318
Xi'an, Shaanxi, China
Local Institution - 0319
Shanghai, SH, China
Local Institution - 0249
Tianjin, Tianjin Municipality, China
Local Institution - 0243
Hangzhou, ZJ, China
Local Institution - 0320
Ningbo, ZJ, China
Local Institution - 0100
Beijing, China
Local Institution - 0216
Beijing, China
Local Institution - 0234
Changsha, China
Local Institution - 0273
Fuzhou, China
Local Institution - 0079
Guangzhou, China
Local Institution - 0212
Jinan, China
Local Institution - 0231
Nanjing, China
Local Institution - 0077
Qingdao, China
Local Institution - 0223
Shanghai, China
Local Institution - 0305
Suzhou, China
Local Institution - 0087
Wenzhou, China
Local Institution - 0248
Wuhan, China
Local Institution - 0084
Wuhan, China
Local Institution - 0302
Montería, COR, Colombia
Local Institution - 0217
Bogotá, Colombia
Local Institution - 0211
Bogotá, Colombia
Local Institution - 0101
Floridablanca, Colombia
Local Institution - 0179
Medellín, Colombia
Local Institution - 0093
Valledupar, Colombia
Local Institution - 0036
Brno, Czechia
Local Institution - 0206
Olomouc, Czechia
Local Institution - 0215
Prague, Czechia
Local Institution - 0069
Prague, Czechia
Local Institution - 0028
Odense, Denmark
Local Institution - 0276
Helsinki, Finland
Local Institution - 0201
Kuopio, Finland
Local Institution - 0030
Amiens, France
Local Institution - 0055
Caen, France
Local Institution - 0050
Créteil, France
Local Institution - 0236
La Roche-sur-Yon, France
Local Institution - 0054
Lille, France
Local Institution - 0221
Limoges, France
Local Institution - 0272
Nantes, France
Local Institution - 0219
Paris, France
Local Institution - 0228
Paris, France
Local Institution - 0051
Toulouse, France
Universitätsklinikum Ulm
Ulm, Baden-Wurttemberg, Germany
Local Institution - 0324
Augsburg, Bavaria, Germany
Klinikum Bayreuth GmbH
Bayreuth, Bavaria, Germany
Universitaetsklinikum Erlangen - Medizinische Klinik 5
Erlangen, Bavaria, Germany
LMU Klinikum der Universitaet Muenchen - Campus Grosshadern - Transplantation
Munich, Bavaria, Germany
Carl-Thiem-Klinikum Cottbus GmbH
Cottbus, Brandenburg, Germany
Local Institution - 0315
Hamburg, Free and Hanseatic City of Hamburg, Germany
Local Institution - 0316
Chemnitz, Saxony, Germany
Local Institution - 0037
Berlin, State of Berlin, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
Local Institution - 0297
Hamburg, Germany
Local Institution - 0026
Hamm, Germany
Local Institution - 0038
Jena, Germany
Local Institution - 0040
Tübingen, Germany
Local Institution - 0209
Thessaloniki, B, Greece
Local Institution - 0097
Rio, G, Greece
Local Institution - 0185
Athens, I, Greece
Local Institution - 0233
Athens, Greece
Local Institution - 0290
Larissa, Greece
Local Institution - 0063
Thessaloniki, Greece
Local Institution - 0250
Hong Kong, HK, Hong Kong
Local Institution - 0062
Debrecen, HB, Hungary
Local Institution - 0128
Chandigarh, Chandigarh, India
Local Institution - 0110
Bangalore, Karnataka, India
Local Institution - 0109
Kochi, Kerala, India
Local Institution - 0200
Kolhāpur, Maharashtra, India
Local Institution - 0152
Nagpur, Maharashtra, India
Local Institution - 0123
Pune, Maharashtra, India
Local Institution - 0142
Pune, Maharashtra, India
Local Institution - 0124
Bhubaneswar, Odisha, India
Local Institution - 0125
Kolkata, West Bengal, India
Local Institution - 0057
Ashdod, Israel
Local Institution - 0137
Beer Ya'Aqov, Israel
Local Institution - 0027
Hadera, Israel
Local Institution - 0047
Haifa, Israel
Local Institution - 0075
Jerusalem, Israel
Local Institution - 0060
Jerusalem, Israel
Local Institution - 0108
Petah Tikva, Israel
Local Institution - 0131
Ramat Gan, Israel
Local Institution - 0053
Catania, CT, Italy
Local Institution - 0306
Florence, FI, Italy
Local Institution - 0115
Genova, GE, Italy
Local Institution - 0188
Milan, MI, Italy
Local Institution - 0071
Milan, MI, Italy
Local Institution - 0139
Pisa, PI, Italy
Local Institution - 0046
Roma, RM, Italy
Local Institution - 0140
Torino, TO, Italy
Local Institution - 0074
Naples, Italy
Local Institution - 0278
Pavia, Italy
Policlinico Umberto I
Rome, Italy
Local Institution - 0106
Shibukawa-shi, Gunma, Japan
Local Institution - 0197
Kamakura-Shi, Kanagawa, Japan
Local Institution - 0198
Kumamoto, Kumamoto, Japan
Local Institution - 0130
Sunto-gun, Shizuoka, Japan
Local Institution - 0141
Chiba, Japan
Local Institution - 0118
Gifu, Japan
Local Institution - 0112
Hiroshima, Japan
Local Institution - 0199
Isehara-shi, Japan
Local Institution - 0330
Itabashi-Ku, Japan
Local Institution - 0111
Kagoshima, Japan
Local Institution - 0144
Kanazawa, Japan
Local Institution - 0122
Kōtoku, Japan
Local Institution - 0121
Maebashi, Japan
Local Institution - 0150
Minatoku, Japan
Local Institution - 0104
Nagasaki, Japan
Local Institution - 0143
Nagoya, Japan
Local Institution - 0329
Nerima-Ku, Japan
Local Institution - 0148
Saitama-Shi, Japan
Local Institution - 0268
Sakaishi, Japan
Local Institution - 0105
Sapporo, Japan
Local Institution - 0132
Sendai, Japan
Local Institution - 0116
Shibuya-ku, Japan
Local Institution - 0283
Monterrey, Nuevo León, Mexico
Local Institution - 0146
Toluca, State of Mexico, Mexico
Local Institution - 0129
Amsterdam, North Holland, Netherlands
Local Institution - 0070
Dordrecht, Netherlands
Local Institution - 0149
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
Local Institution - 0327
Bydgoszcz, Poland
Local Institution - 0195
Gdansk, Poland
Local Institution - 0252
Gliwice, Poland
Local Institution - 0039
Katowice, Poland
Local Institution - 0044
Lublin, Poland
Local Institution - 0119
Warsaw, Poland
Local Institution - 0059
Lodz, Łódź Voivodeship, Poland
Local Institution - 0023
Braga, Portugal
Local Institution - 0151
Coimbra, Portugal
Instituto Português Oncologia do Porto Francisco Gentil, EPE
Porto, Portugal
Local Institution - 0117
Bucharest, B, Romania
Local Institution - 0043
Craiova, Dolj, Romania
Local Institution - 0224
Iași, IS, Romania
Local Institution - 0064
Cluj-Napoca, Jud. Cluj, Romania
Local Institution - 0072
Cluj-Napoca, Romania
Local Institution - 0138
Singapore, Singapore
Local Institution - 0187
Singapore, Singapore
Local Institution - 0145
Busan, South Korea
Local Institution - 0113
Goyang-si, South Korea
Local Institution - 0293
Seongnam-si, Gyeonggi-do, South Korea
Local Institution - 0295
Seoul, South Korea
Local Institution - 0114
Seoul, South Korea
Local Institution - 0225
Ulsan, South Korea
Hospital Clínic de Barcelona
Barcelona, B, Spain
Local Institution - 0169
Cáceres, CC, Spain
Local Institution - 0172
Las Palmas de Gran Canaria, Las Palmas, Spain
Local Institution - 0155
Murcia, MU, Spain
Local Institution - 0166
Oviedo, Principality of Asturias, Spain
Local Institution - 0174
Valencia, VC, Spain
Local Institution - 0232
Badalona, Spain
Local Institution - 0317
Madrid, Spain
Local Institution - 0164
Palma de Mallorca, Spain
Local Institution - 0163
Pamplona, Spain
Local Institution - 0230
Borås, Sweden
Local Institution - 0291
Uddevalla, Sweden
Local Institution - 0175
Kaohsiung City, Taiwan
Local Institution - 0153
Kaohsiung City, Taiwan
Local Institution - 0159
New Taipei City, Taiwan
Local Institution - 0165
Tainan, Taiwan
Local Institution - 0292
Taipei, Taiwan
Local Institution - 0289
Taoyuan, Taiwan
Local Institution - 0167
Ankara, Turkey (Türkiye)
Local Institution - 0287
Çankaya, Turkey (Türkiye)
Local Institution - 0052
Edirne, Turkey (Türkiye)
Local Institution - 0309
Istanbul, Turkey (Türkiye)
Local Institution - 0158
Izmir, Turkey (Türkiye)
Local Institution - 0073
Izmir, Turkey (Türkiye)
Local Institution - 0024
Kayseri, Turkey (Türkiye)
Local Institution - 0032
Yenimahalle, Turkey (Türkiye)
Local Institution - 0173
Aberdeen, ABD, United Kingdom
Local Institution - 0161
Windsor, Berkshire, United Kingdom
Local Institution - 0156
Derby, DBY, United Kingdom
Local Institution - 0162
Bournemouth, DOR, United Kingdom
Local Institution - 0284
Portsmouth, HAM, United Kingdom
Local Institution - 0154
Stoke-on-Trent, Staffordshire, United Kingdom
Local Institution - 0160
Edinburgh, United Kingdom
Local Institution - 0025
London, United Kingdom
Local Institution - 0029
Oxford, United Kingdom