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Circadian Rhythm Disruption in the Hospital Intensive Care Environment
Sponsor: University of Pennsylvania
Summary
Abrupt changes to one's lifestyle disrupt biorhythms. Acute effects are well known from jet lag where transmeridian travel leads to insomnia, fatigue, irritability, gastrointestinal symptoms and other complaints. Several studies in the hospital environment reported dampened and misaligned biorhythms, suggesting that the inpatient experience is replete with circadian disruptors. However, comprehensive assessments of how circadian clocks are affected in intensive care and how this predicts post-operative recovery and risk are largely missing.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
15
Start Date
2023-03-15
Completion Date
2028-12
Last Updated
2026-01-23
Healthy Volunteers
Not specified
Conditions
Interventions
Observation
No intervention
Locations (1)
Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania, United States