Clinical Research Directory

Inclusion Criteria: * The sample will include all the people accommodated in Special hospital Merkur, who sign the informed consent. Patients aged between 18 and 80 years. Patients diagnosed with Diabetes Mellitus (more than 5 years from diagnosis). Participant has adequate circulation to the affected extremity(ies), as demonstrated by at least ONE of the following within 60 days prior to enrolment/randomization: a) Dorsum transcutaneous oxygen test (TcPO2) of study leg(s) with results ≥40mmHg, OR, b) Ankle-Brachial Index (ABI) of study leg(s) with results of ≥ 0.7 and ≤ 1.3, OR; C) Toe-Brachial Index (TBI) of study extremity(ies) with results of ≥ 0.5. Exclusion Criteria: * People who do not give their consent to participate in the study, who do not have a mobile phone, or live in an area not covered by a mobile signal and the Internet. Participant who is pregnant, breast feeding or planning to become pregnant. Participant having multiple foot ulcers, an amputation of the forefoot or an amputation at a more proximal location of the foot. Participant having a cancer disease or life expectancy less than six months as assessed by the investigator or undergoing cancer treatment; Participant having a severe foot infection; Active infection, undrained abscess, or critical colonization of the wound(s) with bacteria in the judgment of the investigator; Participant with Hgb A1c \> 12 percent within 3 months prior to randomization; Participant with a known history of poor compliance with medical treatments.