Clinical Research Directory

Inclusion Criteria: 1. Histological or cytological confirmation of recurrent or refractory advanced solid tumours, and have progressed on standard therapy, or are intolerable for available standard therapy, or there is no available standard therapy. 2. At least one measurable disease for expansion cohorts per Response Evaluation Criteria in Solid Tumours (RECIST) v1.1(phase Ia dose escalation only requires at least one assessable lesion) 3. Eastern Cooperative Oncology Group Performance Status of 0 or 1 4. Agree to provide archived tumor tissue samples of primary or metastatic lesions. 5. Have adequate organ function as described in the protocol. Exclusion Criteria: 1. Women who are pregnant or breastfeeding 2. HBsAg/HBcAb positive and HBV-DNA\>1000 copy/mL;HCV-Ab positive and detection of HCV-RNA suggested viral replication 3. Is currently participating and receiving study medication in another study within 4 week prior to the first dose of study treatment 4. Has an active autoimmune disease that has required systemic treatment in past 2 years. 5. Has an active infection requiring systemic therapy 6. Has received a live vaccine wihtin 30 days of planned start of study treatment 7. Has know history of, or any evidence of interstitial lung disease