Clinical Research Directory

Inclusion Criteria: * Subjects voluntarily participate in the study and sign the informed consent form; * The age is between 18 (inclusive) and 85 (inclusive), regardless of gender; * Body mass index (BMI) ≤ 45; * Clinically diagnosed diabetes foot with moderate and severe pain in peripheral nerve of affected limb (defined as NRS score ≥ 4), the course of disease lasts for more than 12 months, and has been treated with clinical routine standard drugs (mecobalamin α- Lipoic acid, sodium valproate, carbamazepine, gabapentin/pregabalin, etc.) symptoms still exist at least 6 months later; * Glycated hemoglobin\<8%; * Not participating in the drug/medical device test within 3 months before the test; Exclusion Criteria: * Patients who are in poor condition and cannot objectively describe symptoms or cooperate to complete the questionnaire score * Ulcer is red and swollen, or active inflammatory infection; * The affected limb has lesions such as blackening and gangrene of the toe skin; * Those suffering from severe respiratory and cardiovascular diseases, liver and kidney insufficiency, and malignant tumors; * Breast-feeding and pregnant women, or subjects with pregnancy plan within 1 month after the trial (also including male subjects); * The daily dose of opioids is more than 120mg (different drug doses are converted into 120mg morphine sustained-release tablets); * People with allergic diseases and allergic constitution; * Have a history of drug abuse or drug addiction; * There are contraindications to pulsed radio frequency therapy;