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Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors
Sponsor: Pietro Mortini, MD, Prof.
Summary
The goal of this observational study is to characterize the circulating leukocyte profile and the immune T cells distribution within the tumor in patients with malignant brain tumors and to correlate these findings with the oncological outcome. Participants will be subjected to blood sampling before surgery and for 12 months of follow-up. Additional sampling and analysis will be performed on tumor samples.
Official title: Immunophenotype Characterization of Circulating and Tumor Infiltrating Immune Cells in Malignant Brain Tumors.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2022-08-01
Completion Date
2029-08-01
Last Updated
2025-06-11
Healthy Volunteers
No
Interventions
Circulating leukocytes immunophenotype
Blood samples will be tested with flow cytometry in order to characterize leukocyte subpopulations and to evaluate the circulating immunophenotype
Tumor sampling
Immunohistochemical analysis will be performed on tumor samples in order to characterize immune T cells distribution within the tumor.
Locations (1)
IRCCS San Raffaele Scientific Institute
Milan, Milan, Italy