Clinical Research Directory

Inclusion Criteria: * Age \>18; * Signed Informed Consent; * PPI intake for at least 3 months; * Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for at least 15 years; Exclusion criteria * Diagnosed with a gastrointestinal infection within 4 weeks prior to screening; Severe gastrointestinal disorders (e.g. inflammatory bowel diseases) * Received any of the following products/medication prior to screening: systemic antibiotics, prokinetics, prebiotic supplements, probiotic supplements within 4 weeks prior to screening; * Concomitant diseases or other circumstances that suggest that the patients are not eligible for participation in the study