Clinical Research Directory

Inclusion Criteria: 1. Patients are able to provide signed and dated written informed consent prior to any study specific procedures 2. Women are post-menopausal (defined as at least 1 year post cessation of menses) and aged ≥ 45 and ≤ 76 years. Males are aged ≥ 40 years and ≤ 76 years 3. Patients should have suitable veins for cannulation or repeated venipuncture 4. Caucasians 5. BMI: 25-38 kg/m2 6. Diagnosed with T2D at least 1.5 years before the start of the study 7. Relatively well-controlled T2D: HbA1c \< 8.5% 8. Oral glucose lowering medication: metformin only or in combination with sulfonylurea agents and/or on stable dose of a DPPIV inhibitor treatment for at least the last 3 months 9. No signs of active diabetes-related co-morbidities like active cardiovascular diseases, active diabetic foot, polyneuropathy or retinopathy 10. No signs of active liver or kidney malfunction Exclusion Criteria: 1. Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator 2. Participate in physical activity more than 3 times a week 3. Unstable body weight (weight gain or loss \> 5 kg in the last three months) 4. Insulin dependent T2D 5. Patients with congestive heart failure and and/or severe renal and or liver insufficiency or known sodium retention with oedema 6. Patients using Probalan (probenecid), Haldol (haloperidol), Depakene (valproate) or medical products containing corticosteroids 7. Men: Hb \<8.4 mmol/L, Women: Hb \<7.8 mmol/l 8. Any contra-indication MRI scanning. These contra-indications include patients with e.g. the following: * Central nervous system aneurysm clip * Implanted neural stimulator * Implanted cardiac pacemaker of defibrillator * Cochlear implant * Metal containing corpora aliena in the eye or brains