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Microbiome in Head and Neck Squamous Cell Carcinoma
Sponsor: University of Colorado, Denver
Summary
This study aims to determine whether dysbiosis actively contributes to HNSCC and if so, the underlying molecular mechanisms.
Official title: Role of Human Microbiome in Head and Neck Cancer
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2025-05-23
Completion Date
2028-10
Last Updated
2026-02-24
Healthy Volunteers
Not specified
Interventions
Metagenomic sequencing
Shotgun metagenomic sequencing will characterize cancer-associated changes in microbial functional capacity and species/strain-level taxonomic profiles. Metagenomics will provide data on microbial functional capacity along with broader taxonomic classifications.
Metabolic analysis
Metabolic analysis will be conducted using LC/MS-based metabolic analysis. A targeted approach will quantify a panel of 30 compounds including Trp pathway products while a non-targeted approach, when applied to both lipid and aqueous phase compounds, will profile relative changes in compounds that may influence host
Locations (1)
University of Colorado Cancer Center
Aurora, Colorado, United States