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Interstitial Lung Disease and Obstructive Sleep Apnea
Sponsor: Dan Liu
Summary
Clinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with the metagenomic next generation sequencing(mNGS) results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease. All patients undergo polysomnography (PSG) and drug-induced sleep endoscopy(DISE). The biological specimens was obtained for molecular biology or other tests.We detected ZNF331, Claudin1, Claudin2, Claudin3, Claudin4, and IL22 as biomarkers to differentiate the diagnostic efficiency of OSA in ILD, ILD+OSA, OSA, and Ctrl groups, respectively
Official title: Study on the Clinical Characteristics of Interstitial Lung Disease and Obstructive Sleep Apnea
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
70
Start Date
2019-09-01
Completion Date
2026-12-31
Last Updated
2026-02-10
Healthy Volunteers
No
Conditions
Interventions
The relationship between imaging and ROSE and NGS
The correlation between ROSE and NGS in imaging and bronchoscopy of ILD patients was observed
Locations (1)
Tianjin Medical University General Hospital
Tianjin, China