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Determination of the Clonality Profile in Myeloproliferative Neoplasms and Association With the Thrombotic Complications (CLOJAK)
Sponsor: University Hospital, Bordeaux
Summary
Myeloproliferative Neoplasms (MPN) are associated with an increased risk of thrombosis. Platelets, red blood cells (RBC), leukocytes and endothelial cells are involved in these complications. An association with the JAK2V617F allele burden assessed in leukocytes has also been suggested. In some patients the allele burden measured in platelets and red blood cells is higher than the one determined in leukocytes. Our project aims at associating the risk of thrombosis with the allele burden determined in the cell populations (platelets, red blood cells, granulocytes and endothelial cells) and identifying high-risk clonality profiles.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2023-06-19
Completion Date
2025-12
Last Updated
2024-12-17
Healthy Volunteers
No
Conditions
Interventions
Blood sampling
A specific blood sampling will be performed in addition to the classical evaluations that are performed in routine practice
Locations (11)
CHU d'Angers, Service Maladies du Sang
Angers, France
CH de Bayonne, Service Hématologie Clinique
Bayonne, France
CHU de Bordeaux, Service Médecine Interne et Maladies Infectieuses
Bordeaux, France
Institut Bergonié, Service Hématologie Clinique
Bordeaux, France
CHU de Brest, Service Hématologie Clinique
Brest, France
CH de Dax, Service Hématologie Clinique
Dax, France
CH de Libourne, Service Hématologie Clinique
Libourne, France
CH de Mont de Marsan, Service Oncologie
Mont-de-Marsan, France
CHU de Bordeaux, Service Hématologie Biologie
Pessac, France
CHU de Bordeaux, Service Hématologie Clinique et Thérapie Cellulaire
Pessac, France
CHU de Bordeaux, Service Médecine Interne
Pessac, France