Clinical Research Directory

Inclusion Criteria: 1. Male or female patients aged between 20 and 60 years; 2. Single-compartment tibiofemoral osteoarthritis (Kellgren-Lawrence grade ≤ 3); 3. Surgical indication of corrective osteotomy (axial deviation of lower extremities \> 5°); 4. Meniscal deficit of the compartment affected by the overload due to malalignment; 5. Ability and consent of patients to actively participate in the rehabilitation protocol and clinical and radiological follow-up (RX and MRI) 6. Signature of informed consent Exclusion Criteria: 1. Patients who are incapacitated or have neurological disorders that may invalidate the research protocol; 2. Diagnosis of neoplastic diseases; 3. Diagnosis of rheumatoid arthritis, Reiter's syndrome, psoriatic arthritis, gout, ankylosing spondylitis or arthritis resulting from another inflammatory disease; human immunodeficiency virus (HIV) infection, viral hepatitis; chondrocalcinosis; 4. Patients with uncontrolled diabetes mellitus; 5. Patients with uncontrolled thyroid metabolic disorders; 6. Patients abusing alcoholic beverages, drugs or medications; 7. Body Mass Index \> 40; 8. Pregnancy or lactation status or intention to become pregnant during the period of study participation; 9. Patients undergoing knee surgery in the previous 12 months.