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Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
Sponsor: Steno Diabetes Center Copenhagen
Summary
The investigators will conduct a proof-of-principle deep phenotyping 4-weeks caloric restriction intervention study in low birth weight (LBW) subjects with NAFLD and normal birth weight (NBW) controls. Furthermore, the investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition in LBW subjects in LBW individuals with and without NAFLD.
Official title: Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.
Key Details
Gender
All
Age Range
35 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2025-02-01
Completion Date
2025-12
Last Updated
2024-12-03
Healthy Volunteers
No
Conditions
Interventions
Caloric restriction intervention
The intervention consist of 4-weeks limiting daily food intake to a window of 8 hours (8am to 4pm) and water-fasting for the remaining hours of the day. Participants (LBW NAFLD individuals only) will be instructed to eat a balanced diet according to the current dietary guidelines reduced by 20% calories to ensure energy deficit.
No intervention
No intervention