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Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
Sponsor: Steno Diabetes Center Copenhagen
Summary
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.
Official title: Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.
Key Details
Gender
All
Age Range
35 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
8
Start Date
2026-01-01
Completion Date
2026-12
Last Updated
2026-05-04
Healthy Volunteers
No
Conditions
Interventions
Caloric restriction intervention
The intervention consist of 4-weeks low calories diet (LCD) using total meal replacement from NUPO. A dietician will guide the participants an ensure well-being during the intervention.
No intervention
No intervention
Locations (2)
Steno Diabetes Center Aarhus
Aarhus, Denmark
Steno Diabetes Center Copenhagen
Herlev, Denmark