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Effect of Transcranial Near InfraRed Light on Cerebral Function in Young and Healthy Older Subjects: a FMRI Study (TIROC)
Sponsor: University Hospital, Grenoble
Summary
Numerous studies have shown that the extra-cranial application of near infrared light (λ=600-1000nm) (also called transcranial photobiomodulation or tPBM), has a positive impact on brain function in both humans and experimental animal models and a neuroprotective effect in animal models. Several of these studies have reported that tPBM could impart more beneficial effects in aged or diseased brains. The primary objective of this study is to use fMRI to compare the cerebral activations in response to a finger tapping motor task, before and after 24min of tPBM versus sham stimulation, in old and young healthy human subjects. The hypothesis of the investigators is that tPBM improves brain function in participants who will be treated using the active device in comparison with those treated with the sham device and that this effect should will be more pronounced in the older subjects.
Official title: Effect of Transcranial Near InfraRed Light on Cerebral Function in Young and Healthy Older Subjects: a Functional Magnetic Resonance Imaging (fMRI) Study (TIROC)
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2023-09-01
Completion Date
2026-05-15
Last Updated
2024-12-16
Healthy Volunteers
Yes
Conditions
Interventions
ACTIVE Transcranial photobiomodulation (tPBM)
fMRI records before and after ACTIVE Transcranial photobiomodulation (tPBM)
SHAM Transcranial photobiomodulation (tPBM)
fMRI records before and after SHAM Transcranial photobiomodulation (tPBM)
Locations (1)
Clinatec Cea/Chuga
Grenoble, France