Clinical Research Directory

Inclusion Criteria: 1. Between 35 and 65 years old; 2. Han nationality; 3. Diagnosed as ischemic cerebrovascular disease with mild to moderate symptoms; 4. Can communicate normally, complete neuropsychological tests independently, and sign informed consent; 5. No previous surgical history; 6. No contraindications such as PET, MRI and DSA; 7. No history of stroke identified by imaging; 8. No family history of other chronic diseases, cancer, mental illness or dementia; 9. Improved Rankin scale score ≤2; 10. Ischemic symptoms appeared in the carotid area ≤3 months before the visit; 11. In line with the surgical treatment of ischemic cerebrovascular disease; Exclusion Criteria: 1. previous dementia; 2. hearing or visual impairment; 3. Drugs that may or are known to influence cognitive abuse; 4. alcohol addiction; 5. Diagnosis of depression, schizophrenia and other psychiatric diseases; 6. MRI showed severe cerebral infarction; 7. Those allergic to Lactobacillus acidophilus; 8. Baseline CT showed intracranial hemorrhage; 9. ischemic onset accompanied by epilepsy; 10. illiteracy; 11. pregnancy or breastfeeding; 12. any serious medical condition that may interact with treatment;