Clinical Research Directory

Inclusion Criteria: All patients had chronic diabetic foot ulcers that did not heal within six weeks of the incidence. Exclusion Criteria: Patients with acute cellulitis, osteomyelitis, or gangrene anywhere in the affected extremity. Patients with renal, hepatic, neurological, or malignant diseases. Patients with severe protein malnutrition (serum albumin \< 2.0 g/dl) or severe anemia (Hgb \< 7.0 g/dl). Patients with an ankle-brachial index \< 0.7, absence of the dorsalis pedis or posterior tibial artery pulse. Patients who had debridement; pregnancy. Patients who refused to join the study, or to sign the written consent.