Inclusion Criteria:
1. Aged ≥18 years, men or women
2. Severe nonproliferative diabetic retinopathy was diagnosed with any one of the following, according to the International Classification of Clinical Severity of Diabetic Retinopathy: more than 20 intraretinal hemorrhaged spots in any one of four quadrants, definite venous beading in more than two quadrants, or definite intraretinal microvascular changes in more than one quadrant.
3. ETDRS beat corrected visual acuity(BCVA) letter score between 19 and 78 (Snellen equivalent 20/400-20/32) on the day of randomisation.
4. At least partial corneal transparency (or central corneal transparency), good pupil dilation and full cooperation with PRP, and ensure that the fundus examination, visual function examination and optical coherence tomography (OCT) examination can be performed after vitrectomy.
5. Able and willing to sign informed consent
Exclusion Criteria:
1. Unwilling or unable to provide consent for participation in the study, unwilling to submit to the randomisation process or unable to return for the scheduled protocol visits
2. Participating in another clinical trial within the past 3 months.
3. Previous intraocular laser therapy, intraocular surgery (excluding cataract surgery), or scheduled to undergo surgery within the next 6 months
4. Previous poorly controlled glaucoma (defined as intraocular pressure ≥25mmHg after anti-glaucoma medication)
5. Patients previously diagnosed with wet AMD, retinal vein occlusion and other neovascular retinopathy
6. Patients previously diagnosed with macular membrane, ischemic optic neuropathy, uveitis and other definite fundus diseases.
7. Received pro-VEGF or anti-VEGF treatment within the past 3 months (systemic or intravitreal).
8. Has a history of corticosteroid treatment (peribulbar or intravitreal) in the past 3 months
9. Underwent yttrium aluminum garnet capsulotomy within the past 3 months
10. Patients with intraocular fillings of silicone oil or inert gas after treatment
11. Has substantial cataract that, according to the investigator's judgement, is likely to decrease visual acuity by more than three lines (ie, the cataract reduces the visual acuity to 20/40 or worse).
12. Aphakic eye
13. Has severe external ocular infection, including conjunctivitis and substantial blepharitis.
14. Patients with severe cardiopulmonary, liver and kidney impairment and advanced cancer
15. Has blood pressure \>180/110 mm Hg. If blood pressure is maintained below 180/110 mm Hg with antihypertensive medication, the individual is eligible to participate
16. Has a history of transient ischaemic attack, stroke, myocardial infarction, acute congestive heart failure or other acute cardiac event requiring hospitalization within the past 3 months.
17. For women of childbearing age: potential study participants would be questioned about pregnant, lactating or intending to become pregnant within the next 3 years. The investigator would determine when a pregnancy test is required.
