Clinical Research Directory

Inclusion Criteria: Adults (age ≥18 years) diagnosed with non-purulent cellulitis and determined by the treating emergency physician to be eligible for outpatient oral antibiotics. Exclusion Criteria: 1. Age \<18 years; 2. Patient already taking oral antibiotics; 3. Treating physician decides IV antibiotics are required; 4. Abscess requiring an incision and drainage procedure; 5. Known prior skin or soft tissue infection secondary to methicillin-resistant Staphylococcus aureus (MRSA); 6. Cellulitis secondary to a human or animal bite wound; 7. Penetrating wound or water exposure resulting in cellulitis; 8. Surgical site infection; 9. Patient found at a follow up visit to have an alternative, non-infectious etiology (e.g., deep vein thrombosis); 10. bilateral symptoms (e.g., both legs involved); 11. Malignancy and currently being treated with chemotherapy; 12. Solid organ or bone marrow transplant recipient; 13. Renal impairment with an estimated glomerular filtration rate \<30 mL/min documented on the health record at any time within the past three months; 14. Allergy to cephalosporins or history of anaphylaxis to penicillin; 15. Inability to provide informed consent