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ACTIVE NOT RECRUITING
NCT05853068

Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

Sponsor: Dr. Negrin University Hospital

View on ClinicalTrials.gov

Summary

We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV

Official title: Assessment of PaO2/FiO2 Ratio Pre and POst INTubation (The APPOINT Study)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

400

Start Date

2023-04-29

Completion Date

2025-11-30

Last Updated

2025-08-26

Healthy Volunteers

No

Interventions

DEVICE

Mechanical ventilation

Need for endotracheal intubation and invasive mechanical ventilation

Locations (2)

Rush University Medical Center

Chicago, Illinois, United States

Jesús Villar

Las Palmas de Gran Canaria, Las Palmas, Spain