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Assessment of PaO2/FiO2 Ratio Pre and POst INTubation
Sponsor: Dr. Negrin University Hospital
Summary
We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV
Official title: Assessment of PaO2/FiO2 Ratio Pre and POst INTubation (The APPOINT Study)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2023-04-29
Completion Date
2025-11-30
Last Updated
2025-08-26
Healthy Volunteers
No
Conditions
Interventions
Mechanical ventilation
Need for endotracheal intubation and invasive mechanical ventilation
Locations (2)
Rush University Medical Center
Chicago, Illinois, United States
Jesús Villar
Las Palmas de Gran Canaria, Las Palmas, Spain