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Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)
Sponsor: Mirati Therapeutics Inc.
Summary
This study will evaluate the efficacy of two dosing regimens of adagrasib (600 mg BID versus 400 mg BID) in patients with NSCLC with KRAS G12C mutation.
Official title: A Randomized Study of Two Dosing Regimens of Adagrasib in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-02-16
Completion Date
2026-07-30
Last Updated
2026-03-27
Healthy Volunteers
No
Interventions
Adagrasib
KRAS G12C inhibitor
Locations (98)
Local Institution - 101
Santa Rosa, California, United States
Local Institution - 105
Kansas City, Missouri, United States
Local Institution - 100
Durham, North Carolina, United States
Local Institution - 106
Dallas, Texas, United States
Local Institution - 181
Salvador, Estado de Bahia, Brazil
Local Institution - 177
Porto Alegre, Rio Grande do Sul, Brazil
Local Institution - 182
Itajaí, Santa Catarina, Brazil
Local Institution - 178
Belo Horizonte, São Paulo, Brazil
Local Institution - 102
São Paulo, Brazil
Local Institution - 175
São Paulo, Brazil
Local Institution - 527
Zagreb, City of Zagreb, Croatia
Local Institution - 529
Rijeka, Primorje-Gorski Kotar County, Croatia
Local Institution - 559
Grenoble, Auvergne-Rhône-Alpes, France
Local Institution - 556
Pessac, Gironde, France
Local Institution - 553
Saint-Herblain, Loire-Atlantique, France
Local Institution - 554
Angers, Maine-et-Loire, France
Local Institution - 552
Lorient, Morbihan, France
Local Institution - 555
Nantes, Pays de la Loire Region, France
Local Institution - 557
Poitiers, Poitou-Charentes, France
Local Institution - 561
Nice, Provence-Alpes-Côte d'Azur Region, France
Local Institution - 551
Marseille, Rhône, France
Local Institution - 560
Villefranche-sur-Saône, Rhône, France
Local Institution - 562
Paris, France
Local Institution - 558
Quimper, France
Local Institution - 550
Saint-Mandé, France
Local Institution - 577
Pátrai, Achaïa, Greece
Local Institution - 575
Athens, Attica, Greece
Local Institution - 580
Thessaloniki, North Aegean, Greece
Local Institution - 579
Haidari - Athens, Pella, Greece
Local Institution - 576
Thessaloniki, Greece
Local Institution - 581
Thessaloniki, Greece
Local Institution - 625
Jerusalem, Jerusalem, Israel
Local Institution - 629
Haifa, Tel Aviv, Israel
Local Institution - 628
Tel Aviv, Tel Aviv, Israel
Local Institution - 627
Haifa, Israel
Local Institution - 626
Tel Aviv, Israel
Local Institution - 778
Pesaro, Pesaro E Urbino, Italy
Local Institution - 777
Novara, Piedmont, Italy
Local Institution - 780
Candiolo, Torino, Italy
Local Institution - 779
Milan, Italy
Local Institution - 775
Perugia, Italy
Local Institution - 776
Roma, Italy
Local Institution - 401
Tōon, Ehime, Japan
Local Institution - 403
Nishinomiya, Hyôgo [Hyogo], Japan
Local Institution - 402
Kashiwa, Tiba [Chiba], Japan
Local Institution - 400
Osaka, Ôsaka [Osaka], Japan
Local Institution - 129
Colonia Nápoles, Mexico City, Mexico
Local Institution - 127
Colonia Roma, Mexico City, Mexico
Local Institution - 125
Toluca, Mexico
Local Institution - 800
Amsterdam, North Holland, Netherlands
Local Institution - 801
Utrecht, Netherlands
Local Institution - 650
Krakow, Lesser Poland Voivodeship, Poland
Local Institution - 651
Gdynia, Pomeranian Voivodeship, Poland
Local Institution - 653
Lublin, Poland
Local Institution - 732
Cluj-Napoca, Cluj, Romania
Local Institution - 731
Ovidiu, Constanța County, Romania
Local Institution - 729
Craiova, Dolj, Romania
Local Institution - 734
Craiova, Dolj, Romania
Local Institution - 730
Timișoara, Timiș County, Romania
Local Institution - 733
Iași, Romania
Local Institution - 725
Sibiu, Romania
Local Institution - 728
Suceava, Romania
Local Institution - 754
Nis, Vojvodina, Serbia
Local Institution - 752
Kragujevac, Šumadijski Okrug, Serbia
Local Institution - 327
Goyang-si, Gyeonggido [Kyonggi-do], South Korea
Local Institution - 325
Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], South Korea
Local Institution - 328
Seoul, Seoul Teugbyeolsi [Seoul-T'ukp, South Korea
Local Institution - 326
Seoul, Seoul Teugbyeolsi [Seoul-T'ukp, South Korea
Local Institution - 680
Santiago de Compostela, A Coruña, Spain
Local Institution - 678
Málaga, Andalusia, Spain
Local Institution - 685
Palma de Mallorca, Balearic Islands, Spain
Local Institution - 676
Oviedo, Principality of Asturias, Spain
Local Institution - 683
Barcelona, Spain
Local Institution - 687
Barcelona, Spain
Local Institution - 681
Barcelona, Spain
Local Institution - 675
Madrid, Spain
Local Institution - 679
Madrid, Spain
Local Institution - 688
Madrid, Spain
Local Institution - 682
Seville, Spain
Local Institution - 677
Valencia, Spain
Local Institution - 352
Kaohsuing City, Kaohsiung, Taiwan
Local Institution - 353
Taichung, Taichung, Taiwan
Local Institution - 179
Taichung, Taichung, Taiwan
Local Institution - 350
Taichung, Taichung, Taiwan
Local Institution - 376
Muang, Chiang Mai, Thailand
Local Institution - 377
Bangkok, Krung Thep Maha Nakhon [Bangko, Thailand
Local Institution - 375
Khon Kaen, Thailand
Local Institution - 378
Songkhla, Thailand
Local Institution - 705
Ankara, Ankara/Cankaya, Turkey (Türkiye)
Local Institution - 702
Ankara, Etlik/Ankara, Turkey (Türkiye)
Local Institution - 709
Istanbul, Samsun, Turkey (Türkiye)
Local Institution - 710
Istanbul, Samsun, Turkey (Türkiye)
Local Institution - 704
Ankara, Turkey (Türkiye)
Local Institution - 701
Ankara, Turkey (Türkiye)
Local Institution - 706
Ankara, Turkey (Türkiye)
Local Institution - 700
Edirne, Turkey (Türkiye)
Local Institution - 707
Istanbul, Turkey (Türkiye)
Local Institution - 708
Izmir, Turkey (Türkiye)