Clinical Research Directory

Inclusion Criteria: * Patient 18 years of age or older, * Patient who has given his/her non-opposition to participate in this study, or alternatively, patient for whom a relative has given his/her non-opposition to participate in this study, * Patient admitted to intensive care for less than 24 hours, * Patient with ARDS according to the Berlin criteria, * Hypoxemia with PaO2/FiO2 ratio ≤ 300 on mechanical ventilation under PEEP ≥ 5 cmH2O, * Bilateral alveolar-interstitial opacities on chest imaging (chest X-ray or CT), * Exclusion of a cardiogenic cause on echocardiography, * Acute or subacute onset within 7 days based on the clinical-radiological profile. Exclusion Criteria: * Positive SARS-CoV-2 PCR in a pharyngeal or respiratory sample (cytobacteriological examination of sputum, bronchial aspiration or bronchoalveolar lavage) prior to admission to the intensive care unit, * Patient with a pathology affecting the coagulation process or endothelial function (hemophilia, von Willebrand disease, etc.), * Patient receiving curative anticoagulant treatment before admission to the intensive care unit, * Patient undergoing extracorporeal veno-venous respiratory assistance (ECMO-VV) before admission to the intensive care unit, * Patient undergoing extra-renal purification with systemic anticoagulation with heparin before admission to the intensive care unit, * Persons referred to in articles L. 1121-5 to L. 1121-8 of the Public Health Code (minor patients, adult patients under tutorship or guardianship, patients deprived of their liberty, pregnant or nursing women), * Moribund patients for whom the life expectancy is less than 24 hours according to the opinion of the investigating physician.